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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Study Abroad Fair presents exciting opportunities
2013-04-23

 

Staff and students gain a wealth of information at the first Study Abroad Fair hosted on the Bloemfontein Campus.
Photo: Stephen Collett
23 April 2013

Kovsie staff and students gained a wealth of information at the first Study Abroad Fair hosted by the Office for International Affairs on the Bloemfontein Campus.

Representatives from partner universities across the USA, Europe and Asia took part in the fair, giving information on study opportunities abroad. They were joined by representatives of international funding agencies and foreign missions from countries including Canada, Indonesia, France and the Republic of Azerbaijan, who gave information on funding opportunities to study overseas.

Welcoming visitors, Ms Dineo Gaofhiwe-Ingram, Assistant Director: Internationalisation, said international education forms a very important and critical part of the university’s strategy of aiming and working towards becoming a research intensive university.

“I believe all here understand and know the value of an international education, both as a donor agency, as an embassy that has bilateral agreements with the South African government to support education, and as a staff member that is here with students to encourage them to go abroad. It is important that our staff and students get to learn and experience from others and others from them.”

Dr Choice Makhetha, Vice-Rector: External Relations, encouraged Kovsies “to visit the world and bring the world back to the UFS.”

Prof Jonathan Jansen, Vice-Chancellor and Rector, had a similar message, talking about the advantages of seeing the world. “You never get to be a good leader unless your sense of the world is bigger than yourself. My goal is to make sure that almost every undergraduate student has some experience of studying abroad.“

List of Exhibitors who took part in the Study Abroad Fair:

1. Funding Agencies
Embassy of USA
Embassy of France
Embassy of The Republic of Azerbaijan
European Union
Embassy of Canada
National Research Foundation (NRF)
Embassy of Switzerland
Embassy of Indonesia
Czech Republic Embassy
Research Africa
British Council

2. Partner Universities Abroad
Mahasarakham University (Thailand)
Appalachian State University (USA)
University of Brussels
Radboud University Nijmegen
The Hague University of Applied Sciences
University of Bremen
VU University Amsterdam
University of Groningen
University of Antwerp
University of Leuven
Jönköping University

3. UFS Representation
Postgraduate School (UFS)
Office for International Affairs (UFS)
Faculty of Education (UFS)
Department of Plant Sciences (UFS)
Department of Social Work (UFS)

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