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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

First-year students encouraged to attend UFS welcoming function
2006-01-12

The University of the Free State (UFS) will host a welcoming function for all new first-year students and their parents on Saturday 14 January 2006 in the Callie Human Centre on the Main Campus in Bloemfontein.

The function starts at 11:00 and will be addressed by the Rector and Vice-Chancellor of the UFS, Prof Frederick Fourie. UFS staff will also be available to provide vital information to first-year students on academic matters.

According to Mr Vernon Collett, Registrar: Academic Student Services at the UFS, Saturday’s welcoming function can assist students and parents by providing vital information on the many high quality academic learning programmes on offer at the UFS in six faculties.

“If students and parents have this information it will make the registration process, which starts next week Tuesday 17 January 2006, much smoother,” Mr Collett said.

The UFS has split the registration process into various categories of students and Mr Collett appealed to all students to adhere to the dates and times which apply to them as a one-stop service will be available so as to avoid unnecessary delays in the registration process.

The registration of first-time entering first-year students who applied before 30 November 2005 to study at the Bloemfontein Campus will take place from Tuesday 17 January 2006 at the Callie Human Centre.

Senior undergraduate students (that is, students entering their second or later year of study) may register from 23 January 2006.

Postgraduate students, first-time entering first-year students and other students who applied for admission to the main campus after 30 November 2005 must register at the Callie Human from 2 February 2006. 

Late applications will be accepted until Wednesday 25 January 2006 at the Information Centre on the Main Campus’ Thakaneng Bridge. These applications will be regarded as pending and will be processed as places become available on the programme the student has applied for,” said Mr Collett. 

Vista Campus:
The Vista Campus in Bloemfontein – which was incorporated into the UFS in January 2004 – no longer accepts applications from first-year students. Such prospective students had to apply to the UFS Main Campus. Students who had been registered on the Vista campus last year must register at the Vista Campus on the same dates as applicable on the Main Campus.

Qwaqwa Campus:
At the Qwaqwa Campus of the UFS, all first-time entering first-year students must report on Thursday 19 January 2006, after which the registration of these students will take place according to a specific programme. The official welcoming functioning for new first-years at the Qwaqwa campus of the UFS will take place on Saturday 11 February 2006 at 08:00 in the Rolihlahla Mandela Hall on the Qwaqwa Campus.

Mr Collett appealed to first-year students who have applied to study at the Qwaqwa Campus and their parents to attend this function which fulfils the same role as the one held on the Bloemfontein Main Campus.

Detailed information on the dates and times of registration for the various faculties and academic learning programmes is available on the UFS website at www.uovs.ac.za. Prospective students may also call the Main Campus in Bloemfontein on (051) 401-3000 or the Qwaqwa Campus on (058) 718-5000 for more information.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
10 January 2006

 

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