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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

“Leisure can be of great geographical importance”
2013-09-26

 

Prof Gustav Etienne Visser
Photo: Supplied
26 September 2013
 

Prof Gustav Etienne Visser (43) is Professor in Human Geography at the University of the Free State. He has been with the university’s Geography Department since January 2002 and became a full professor in 2009.
Visser completed his MA in Geographical Research at the Stellenbosch University in 1996 and finished his PhD in Geography at the London School of Economics and Political Science in 2000. His thesis was titled: Spatialities of social justice: reflections on South African Cities.

Visser was a Post-doctoral Fellow at the School of Geography, Archaeology and Environmental Studies at the University of the Witwatersrand before his appointment at the UFS. He now teaches Urban Geography to third-year students and Tourism and Development to MA students.

His research interests so far have been Identity-based consumption and urban morphological change, Tourism and development nexus and Critical reflections on South African Geographical Research.

Visser’s publications summary is as follows:

- Four books – edited collections
- 28 book chapters
- 71 refereed articles
- Nine academic commentaries and research notes
- 14 research reports
- and 38 conference papers

His latest research on how people’s leisure time influences our urban spaces, is fundamentally relevant to everyday life.

“We tend to forget to think about it, but how people spend their leisure time is part of their lifestyle,” says Visser.“ And our urban surroundings are influenced by the lifestyles of its inhabitants.”

When asked about his own leisure time and activities, Visser humorously responds “There is no such thing.”

However, he is passionate about eating, cooking and wine.
“I must also watch a series every day – Dexter is definitely my favourite.
“Furthermore, I also travel abroad for about three months of the year, which is mainly for my research concerning urban spaces.”

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