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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS academic discusses Dutch, Afrikaans and African languages
2006-05-22

During the colloquium presented in Belgium by the Province Antwerp were from the left Prof Pol Cuvelier (University of Antwerp), Prof Theo du Plessis (Director: Unit for Language Management at the UFS), Mr Ludo Helsen (Permanent Deputy: Province of Antwerp) and Mr Jean-Pierre Rondas (Flemish radio journalist).

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UFS academic discusses Dutch, Afrikaans and African languages at international conference

Prof Theo du Plessis, Director of the Unit for Language Management at the University of the Free State (UFS), was the main speaker at a colloquium titled “Routes:  Where to now? - Een traject van het Nederlands naar het Afrikaans en de Afrikatalen”, which was recently presented by the Province Antwerp in Belgium.

 The aim of the colloquium was to discuss the future cooperation in the field of language between the Province Antwerp and South Africa. 

 The Province Antwerp is already involved with projects in South Africa.  One of these projects is the Multilingual Information Development Programme (MIDP), a partnership project between the UFS and the Free State Province that is mainly funded by the Province Antwerp. 

 The project has been running since 1999 and was recently in the news with the presentation of a symposium on multilingualism and exclusion on the Main Campus of the UFS.  It is hoped that the Routes colloquium will indicate new stages on which can be added to the already successful cooperation in the area of language.

 Prof Du Plessis’s presentation titled “Nederlands, Afrikaans en die Afrikatale – kan samewerking slaag? Die geval MIDP in die Vrystaat”, investigated the successes that have been made with the MIDP.  He discussed two possible approaches to cooperation in the areas of language, that of a sentimentalistic  approach against an instrumentalistic approach. 

Cooperation in the first approach makes language the aim.  In the second approach language is used as a means to a greater aim.  According to Prof du Plessis the first approach is driven by a romantisised idea about the relation between the Flemish and Afrikaans speaking people, which may unfortunately polarise the position of Afrikaans in South Africa even further.

 He argues that, given the time that we are in, the second approach will deliver more constructive results as language can among others be used for to further  democracy in South Africa.   This can happen by cooperation in the institutionalising of multilingualism in our society.  The more languages are used in education, law and government administration, the more we can be assured a successful democracy.

 The Routes colloquium was facilitated by the well-known Flemish radio journalist, Jean-Pierre Rondas. About twenty South African and Flemish language specialists took part in the colloquium.  Dr Fritz Kok, outgoing chief executive officer of the ATKV took part in the opening ceremony and Dr Neville Alexander from the University of Cape Town and well-known activist for multilingualism in South Africa was also one of the main speakers.

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