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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

DF Malan – the politician, the man and Lindie Koorts’ award behind it
2014-04-30

 
Lindie Koorts
Photo: Hannes Pieterse
Sometimes fact is stranger than fiction. In this case, it is not only true, but fact is stirring up more of a buzz than make-belief does.

The first biography of an apartheid Prime Minister written since 1994, won an award at the 2014 Woordfees. ‘DF Malan and the Rise of Afrikaner Nationalism’ is the title of the book causing this national whirlwind. The author: Lindie Koorts – a postdoctoral fellow at the UFS’s Centre for Africa Studies.

She admits she was among the most surprised when she won the category for Debut Writers. “This is, as far as I know, the first time this prize goes to a non-fiction writer,” Koorts said.

What started as curiosity around DF Malan, four years later culminated in an objective biography devoid of justification or exoneration. “Throughout the process of writing, I offer the facts, but I do not clamber in with moralistic judgements,” Koorts said.

In addition to Malan the politician, Koorts discovered Malan the human being as well during her research. When she stumbled on his hand-written love letters to Maria Louw, which he wrote when he was in his 60s, a totally different man emerged. “I felt like a teenager while reading those letters!” Koorts laughed.

In the chapter entitled Coalition and Fusion, this dynamic historian unearthed a fact that had the power to change the course of history. Up until this point, the belief was held that one party deceived another. However, Koorts’ research proves that the entire issue rested on a letter that did not arrive on time. A case of tardy train schedules and a mere misunderstanding.

“To be able to unravel these things makes one feel that you have succeeded in something,” she said.

Not only did she succeed in writing an award-winning biography, she surely will be making history as she goes.

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