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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Stakeholders endorse UFS’s vision and strategy
2014-05-27

Results from a perception audit commissioned by the University of the Free State (UFS) in February 2014 have been finalised. The audit indicates that 86,14% of the university’s internal and external stakeholders agree with the institution's stated vision. An average of 81,99% of stakeholders endorse our values and 81,28% agree with our goals. 

The study was commissioned by the university's Department of Communication and Brand Management and conducted by an external firm of independent researchers. It was aimed at determining internal and external stakeholder understanding and endorsement of university strategy, as well as tracking core reputational indicators and perceptions.

The study was conducted among a representative sample of 23 stakeholder groupings, including staff, current and prospective students, donors, alumni, school principals, community leaders, potential employers of students and international partner universities.

Two similar audits were conducted in the last ten years – in 2005 and again in 2008 after the Reitz incident. Although a direct comparison of findings would not be psychometrically rigorous due to differing research modelling and sampling methods, there is a strong indication that the perception of the institution's stakeholders has shifted.

The uniqueness of the study and the research model developed for the project have recently received international recognition from the International Association of Business Communicators (IABC). The prestigious Jack Whittmer Research Award was presented to the university on 9 June 2014 during the Excellence Awards Gala of the association's world conference held in Toronto, Canada.

Read the full release (pdf)

 

 

Issued by: Lacea Loader (Director: Communication and Brand Management)
Tel: +27(0)51 401 2584 or +27(0)83 645 2454
E-mail: news@ufs.ac.za
Fax: +27(0)51 444 6393

 

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