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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Is Al-Qaeda operating in South Africa?
2014-09-29

 
Our Department of Political Studies and Governance recently hosted a seminar with investigative journalist De Wet Potgieter – author of the book, ‘Black Widow White Widow’.During the seminar, Potgieter reflected on the research he has conducted for the book, revealing the unsettling presence of Al-Qaeda in South Africa.

The ‘White Widow’ in the book’s title refers to Samantha Lewthwaite, a British woman who was found in South Africa with a fraudulent passport. She was later linked to the Westgate shopping mall attack which took place in Nairobi, Kenya on 21 September 2013. In this mass shooting at least 67 people died and over 175 people were wounded. The Islamist group al-Shabaab – which is also linked to Al-Qaeda – claimed responsibility for the incident.

In contrast, the ‘Black Widow’ is the disclosed identity of an Afrikaans-speaking self-styled spy, who after being widowed became a counter-terrorist operative.

Potgieter’s book divulges details of Al-Qaeda paramilitary and urban warfare training on a secluded farm in the Little Karoo and reveals details of the support they receive from various local extremist groups. Potgieter’s investigation spans across two years and suggests possible future attacks from, or on, South African soil.

“South Africa plays a role in the bigger picture for Al-Qaeda Islamic terrorism,” Potgieter said. “For instance, the Navy Seal team who killed Bin Laden found reports pointing to active Al-Qaeda/Islamist presence in South Africa. South Africans need to know we are under siege by a small, well-trained Al Qaeda terrorist cell. Yet, operations – of which I know, but cannot disclose much – are also underway to contain these matters,” Potgieter added.

Potgieter’s sources suggest that Al-Qaeda has been active in South Africa since the 2010 FIFA World Cup already. The South African government seems to turn a blind eye, though, despite CIA and MI6 requests and enquiries on the matter.


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