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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Dr Abdon Atangana cements his research globally by solving fractional calculus problem
2014-12-03

 

Dr Abdon Atangana

To publish 29 papers in respected international journals – and all of that in one year – is no mean feat. Postdoctoral researcher Abdon Atangana at the Institute for Groundwater Studies at the University of the Free State (UFS) reached this mark by October 2014, shortly before his 29th birthday.

His latest paper, ‘Modelling the Advancement of the Impurities and the Melted Oxygen concentration within the Scope of Fractional Calculus’, has been accepted for publication by the International Journal of Non-Linear Mechanics.

In previously-published research he solved a problem in the field of fractional calculus by introducing a fractional derivative called ‘Beta-derivative’ and its anti-derivative called ‘Atangana-Beta integral’, thereby cementing his research in this field.

Dr Atangana, originally from Cameroon, received his PhD in Geohydrology at the UFS in 2013. His research interests include:
• the theory of fractional calculus;
• modelling real world problems with fractional order derivatives;
• applications of fractional calculus;
• analytical methods for partial differential equations;
• analytical methods for ordinary differential equations;
• numerical methods for partial and ordinary differential equations; and
• iterative methods and uncertainties modelling.

Dr Atangana says that, “Applied mathematics can be regarded as the bridge between theory and practice. The use of mathematical tools for solving real world problems is as old as creation itself. As written in the book Genesis ‘And God saw the light, that it was good; and divided the light from the darkness’, the word division appears here as the well-known method of separation of variables, this method is usually employed to solve a class of linear partial differential equations”.

“A mathematical model is a depiction of a system using mathematical concepts and language. The procedure of developing a mathematical model is termed mathematical modelling. Mathematical models are used not only in natural sciences, but also in social sciences such as economics, psychology, sociology and political sciences. These models help to explain systems and to study the effects of different components, and to make predictions about behaviours.”

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