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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

SRC and student parliament elections declared free and fair
2004-08-17

The Electoral Institute of Southern Africa (EISA) has certified the University of the Free State ’s (UFS) election process today ( Friday 13 August 2004 ) and declared it free and fair.

The process to elect a Student Representative Council (SRC) and Student Parliament started on 2 August 2004 and ended today with the announcement of the results.

“No objections regarding the voting process were received and the preliminary results were announced last night. A total of 2192 votes were cast, while 416 votes were spoilt,” said Mr Seth Phamuli, Chief Electoral Officer (CEO) of EISA.

Mr Alfred Geldenhuys, third year student in B Com Human Resource Management, was declared the SRC President for 2004/2005. Mr Geldenhuys was SRC representative for Campus Matters in 2003/2004.

The other members of the SRC are:

Vice-President: Annelise de Kock (fourth year student in B Sc Dietetics)

Secretary: Michelle du Plessis (third year student in B Sc)

Treasurer: Dida Coetzer (third year student in B Rek)

Academics: Cherese Laubscher (third year student in MB Ch B)

Ladies Internal Liaison: Tanya de Jager (third year student in B Ed Intermediary Phase)

Men’s Internal Liaison: Stef Conradie (third year student in BA Human Movement Science)

Transformation: Clayton van der Ross (second year student in B Com Human Resources Management)

Arts and Culture: AC Geldenhuys (second year student in B Acc)

Recreation and Internal

Affairs: Khotso Motloung (third year student in B Com Accounting)

Campus Services: Sylvanus Watson (fourth year student in B Sc Agric)

Constitutional and

Legal Affairs: Lerato Mofoti (fourth year student in LLB)

Dialogue and

Associations: Owen Kumalo (third year student in B Com Sport Management)

Kovscom: Estel Scheepers (third year student in BA Integrated Marketing)

Sport: Graeme Bradley (second year student in B Com Human Resources Management)

Student Development: Werner du Preez (third year student in B Com Economics)

Irawa: Jeanri-Tine van Zyl (second year student in BA Media Studies)

In the Student Parliament the African Christian Democratic Party (ACDP) and the Kovsie Alliance were each granted seven seats, whilst the Here XVII was granted 11 seats.

MEDIAVERKLARING

Uitgereik deur: Lacea Loader
Mediaverteenwoordiger
Tel: (051) 401-2584
Sel: 083 645 2454
E-pos: loaderl.stg@mail.uovs.ac.za
 

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