Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Prof Helene Strauss delves into the emotion and politics of contemporary South African protest cultures
2014-12-22

Prof Helene Strauss from the University of the Free State’s (UFS) Department of English currently researches the relationship between emotion and politics in contemporary South African public and protest cultures.

The research foregrounds the complex set of concerns opened up by a study of intimacy, read as not simply a sign for emotional and sexual closeness, but more broadly as a complexly mediated site from which to observe the embodied, affective coordinates of various forms of control and contestation. Through the analysis of a range of cultural texts that, for instance, recompose moments of spectacular social upheaval through the lenses of everyday, embodied experience, this research considers what aesthetic responsibility might mean in both post-transitional South Africa and elsewhere.

One aspect of this research charts a gradual shift in South Africa from what is frequently referred to as the ‘liberation euphoria’ of the mid- to late 1990s – and the optimistic fantasies of a future South Africa that characterised dominant public discourse in the period immediately following the political transition – toward an emotional culture in which expressions of anger, disillusionment and disappointment seem to have become relatively widespread.

Prof Strauss asks, for instance, how these public feelings have been managed in the aftermath of events such as the Marikana massacre, and suggests that the affective and temporal dimensions of current attempts at containing perceived threats to financial and political stability on the part of South Africa’s business and political elite are key to understanding increasingly violent and repressive securitisation strategies.

Earlier this year, Prof Strauss presented papers on aspects of this research at two international conferences: (i) the Association for Cultural Studies conference in Tampere, Finland, where she was invited to be part of a ‘Spotlight Panel’ on the topic of African Cultural Studies, (ii) and at a conference at McMaster University in Hamilton, Canada, which she helped to co-organise.

An article based on some of this work has been published in the journal Safundi.

For more of Prof Strauss’s research published in journals, follow the links below:
http://www.tandfonline.com/toc/rsaf20/current#.VAf88_mSxqU
http://www.tandfonline.com/toc/riij20/15/1#.VAf80vmSxqU
http://www.palgrave-journals.com/sub/journal/v4/n2/index.html

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept