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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

A tale of many cities – new dictionary of place names reveals our heritage
2015-01-28

 

‘The Dictionary of Southern African Place Names’ provides not only the answers, but also gives insight into how our places and our people were shaped. Penned by three academics from the University of the Free State (UFS), it is the fourth edition of this fascinating book.

Prof Peter Raper from the UFS Unit for Language Facilitation and Empowerment, together with his colleagues Prof Theodorus du Plessis and Dr Lucie Möller, created more than a reference book. They provide the reader with deeper understanding of events, our heroes, beliefs, values, fears and aspirations.

Jonathan Ball Publishers describes the book as “the most comprehensive glossary of Southern African towns, villages, railway stations, mountains, rivers and beaches. The 9 000 short entries incorporate data from sources dating as far back as 1486, encapsulating the linguistic and cultural heritage of all the peoples of the subcontinent, past and present.”

And what would the origin of the name Bloemfontein be?

This dictionary provides the following answer.

“Capital city of the Free State and judicial capital of South Africa. It was established in 1846 by Major HD Warden at a fountain on the farm Bloemfontein, originally owned by a Griqua, Mauritz Pretorius. It has been claimed to have been named after a person with the surname Bloem, or in honour of the Khoikhoi chief Jan Bloem, or after an ox with this name. Probably, however, it was named after flowers growing at the fountain, from Dutch bloem, ‘flower’, fonteijn, ‘spring’. The name is thought to be a translation from a Bushman name of which Mangaung is the Sotho adaptation; ma- is the Sotho plural prefix or class marker; the component ngau is comparable to the Bushman word //au, ‘flower’, and the final ng is cognate with the locative demonstrative ?, ‘that (one) there’. Bloemfontein attained municipal status in 1880.”




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