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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

First-years at South Campus step into a bright future
2015-02-05

Photo: Stefan Lotter

This is the first step to a bright future.

This was the resounding message that welcomed first-year students to the South Campus. “Remember,” Tshegofatso Setilo, Manager of the University Preparation Programme said, “a journey of a thousand miles begins with the first step.” But please do not get discouraged on your way, she urged, because “this is your first step to a bright future.

In his welcoming message, Prof Nicky Morgan, Vice-Rector: Operations at the UFS referred to the South Campus as the giant of the south. “This is one of the trailblazing campuses of the university,” he said. “No doubt what you’ll experience on this campus, you’ll never forget.”

This year, the South Campus boasts with 1 200 first-year students taking part in our University Preparation and Extended Programmes. These programmes allow students – whose matric marks did not reach the required total – the opportunity to study at the University of the Free State (UFS). The result? An astounding rise in pass rates. Some of the students on the South Campus outperform their peers studying at the Bloemfontein Campus, Prof Morgan remarked.

“You’ve got it in yourself. You’ve got the potential to unleash yourself on the world,” Prof Morgan said. You do not always realise the value of something that has come your way, he said. So, every moment you get an opportunity, he advised, use it to shape your future.

Addressing the newcomers’ fears, Prof Morgan urged each student to open themselves to the good and new experiences waiting for them. “When you find yourself in a new space, it always begins with you,” he said. Learn to understand how to live in harmony in different spaces.

Prof Morgan placed great emphasis on his closing remark: “At university, the more questions you seek to have answered – they’re worth more than the answers you have.”

 

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