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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

UFS appoints new council members
2004-06-07

 

The council of the University of the Free State (UFS) last week appointed two new council members. One of the members, Mrs Busiswa Tshabalala, will represent the Qwaqwa community. It is the first time since the incorporation of the Qwaqwa into the UFS campus last year that a council member was elected to represent the Qwaqwa community.

Mrs Tshabalala obtained her BA Hons in History from the University of the North’s Qwaqwa campus in 1992 and a B Ed degree in leadership management from the UFS in 1998. She was the first female deputy principal at the Harrismith Secondary School (1989-1992) and principal of the Forty Second Hill Teachers’ Centre in the Vrede area office of the Free State Department of Education. In 2001 she was seconded by the Free State Department of Education to coordinate programme 1 and 2 for Link Community Development. She is currently the director of the Thabo Mofutsanyana education district of the Free State Department of Education.

Dr Susan Vosloo, international acclaimed cardiologist, is the other new member of the council. Dr Vosloo, old Kovsie of the year 1989, obtained the MB Chb degree in 1980 at the UFS, an M Med cardiothoracic surgery and in 1998 the FCS (SA) qualification in cardiothoracic surgery at the College of Medicine of South Africa (CMSA). Dr Vosloo’s career extends over a wide spectrum and she specialises in pediatric and adult cardiothoracic surgery. In 1993 she took part in the first heart transplant in Johannesburg at Milpark Hospital, in 1997 she did the first hear-lung transplant at City Park Hospital in Cape Town and in 1997 a heart transplant on a 3-year old child.

She has a cardiothoracic surgery at the Christiaan Barnard Memorial Hospital in Cape Town since 1991 and in also part-time involved with the Red Cross Memorial Hospital in Cape Town.

“It is a great honour for the UFS to welcome two women with so much expertise and experience on the council. Their presence strengthens the UFS’s continued effort to transform the council,” said judge Faan Hancke, chairperson of the UFS council..

Both Mrs Tshabalala and Dr Vosloo’s appointments are until June 2008.

The following council members have been re-elected until June 2008:

Prof Dines Gihwala - vice-chairperson of the council
Dr Nathan Bagarette
Dr Frans Kotzé

Dr Kobus Laubscher was elected by the donors as representative for a further term until June 2008. Me Winifred Hoexter was elected by the Alumni as the third representative. She has been a foundation donor of the UFS since 1997 and committee member of the Kovsie Alumni Trust since 2000. Me Hoexter’s term is until June 2008. The other Alumni representatives are judge Faan Hancke and Mr Jan Grobler, whose term is until June 2006.


Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za

7 June 2004

 

 

Mrs Busiswa Tshabalala

Dr Susan Vosloo

 

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