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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Tough future if nothing changes in Africa
2015-02-20

 

The Department of Political Studies and Governance at the UFS recently hosted a workshop with the Osaka School for International Public Policy and the Southern African Centre for Collaboration in Peace and Security Studies.

The workshop, which was held on Thursday 12 February, had the theme of Perspectives on African Peace and Security. During workshop sessions, thoughts and views on peace and security were discussed for both African and South African circumstances. This was the fourth year of this joint workshop at the UFS.

Prof Hussein Solomon from the Department of Political Studies and Governance at the UFS shared some notes:

“In terms of South Africa, the fact that only 11% of South Africans have a post-school education holds negative prospects for us attaining a so-called ‘knowledge economy’”, says Prof Solomon.

“This also means that unemployment will continue to remain high since, in certain key areas, the South African economy is quite sophisticated, and needs a sophisticated labour force. Therefore, high unemployment translates into further social unrest, especially if one considers that youth unemployment is approaching 50%.”
 
Moving to broader issues in Africa, Solomon states that governance remains a challenge.

“There is a need to move away from Eurocentric forms of governance to more hybrid forms, implementing a mix of western forms of governance alongside more traditional forms.”

“Otherwise, the probability of conflict remains high as we look into the future. The possibility of water wars between African states is distinct.”

“Terrorism too will be with us for some time to come, with three terrorist attacks per day in Africa. Making matters worse, whether it is conflict over water or terrorist atrocities, is the African Union’s inability to resolve these issues. It simply does not have the capacity”, says Solomon.

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