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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

SRC Consultation desk
2015-04-20

In an era where woman are consistently escalating up the echelons of power, this universal phenomenon is also making waves on the Bloemfontein Campus of the University of the Free State. As different citizens would recognise First lady Michelle Obama, Public Protector Thuli Madonsela, German Chancellor Angela Merkel and United Nations Ambassador Angelina Jolie, so it is also with Student Representative Council Secretary General, Dineo Motaung. She is among a handful of ladies within the student leadership who cherish her responsibilities diligently for the interests of human beings.

The SRC Consultation Desk is an official space created by the office of the Secretary General, aimed at being of service to students alongside the students’ academic pursuit. Inspired by Ubuntu, meaning ‘I am what I am because of who we are’ comes the task of cultivating and nurturing the essence of who we are, through constructive and honest dialogue between students and the university staff. It is by talking to one another that we will establish an environment that permeates our uniqueness and pollinates our consciousness with awareness that would cause us to act in unison in propagating the vision of the university.

Toward this end, the Secretary General has commissioned two SRC members to various stations every Monday and Wednesday, to interact with both students and staff. Please find the schedule reflected below. It is hoped that through this engagement, problems will not simply be identified, but that practical and feasible solutions will be offered.

“Through the SRC Consultation Desk I hope to see the manifestation and spirit of Ubuntu on campus by the time my term ends. With all that said, I am available for any concerns,” said Motaung.

Monday 20 April 2015, 12:00-13:00

SRC Accessibility and Student Support: Louzanne Coetzee

Station: Thakaneng Bridge

Wednesday 23 April 2015, 14:00-15:00

SRC Media, Marketing & Laison: Lethabo Maebana

Station: New Computer Labs (Entrance door)

Wednesday 29 April 2015, 14:00-15:00

SRC Student Development and Environmental Affairs: Victor Ngubeni

Station: Sasol Library (Opposite Deli)

Monday 4 May 2015, 14:00-15:00

SRC Secretary General Dineo Motaung

Station: Amphitheatre             

Wednesday 6 May 2015

SRC Student Media: Masingi Sam

Station: Sasol Library (close to Deli)

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