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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

KovsieSport celebrates three varsity tournaments' titles
2015-04-21

Both staff and students celebrated the Shimlas, KovsieTennis, and KovsieNetball’s achievements.
Photos: Hannes Pieterse

 

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In this week of graduation ceremonies, the University of the Free State had more than its academic achievements to celebrate. The Shimlas’ brilliant triumph in the Varsity Cup as well as the achievements by KovsieTennis and Kovsie Netball was celebrated at a colourful event on the Bloemfontein Campus.

At the celebrations, which were well supported by the campus community, the Vice-Chancellor and Rector, Prof Jonathan Jansen, congratulated all three teams on their outstanding achievements. Not only did the Shimlas walk off with the Varsity Cup, they also won every game they played. AJ Coertzen, the Shimlas’ captain, said: “Although we were well prepared and physically fit, the fact that we played for one another contributed much to our success. As a team, we have grown from friends to brothers.”

KovsieTennis was congratulated on wearing the USSA tennis crown for the fourth consecutive year. In addition, they have the following triumphs to their name: 2007 – SASSU (South African Students Sports Union) (Ladies); 2008 – USSA (University Sport South Africa) (Ladies) and 2009 USSA (Men). Duke Munroe, captain of the KovsieTennis team took the opportunity to thank the team personnel. He believes that hard work behind the scenes by the coach, Marnus Kleinhans, and the team manager, Janine de Kock, contributed greatly to the team’s success.

KovsieNetball was also praised for their successes. In 2014, under the captaincy of Karla Mostert, they won gold at the Varsity Netball championships. They also won the National Premier League. The UFS is also proud of its netball players in various national teams: SA Under 19-23, the Protea groups, and the SA University team.

At the celebrations, Karla said: “The environment and the people you surround yourself with dictate how easily you achieve success. Our achievements and successes are evidence of the quality of the coaches, supporters, and facilities available to us.

After the event on the Red Square, the teams made an appearance in the Callie Human Centre, where they were enthusiastically congratulated by graduands, their families and the university management. Dr Khotso Mokhele, Chancellor of the UFS, also praised the teams for their achievements. “You are a team without individual stars. That is the sort of team I want to be part of.”

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