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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Universal Access and Universal Design approach align UFS with international standards
2015-08-11

Making mobility for students with disabilities easier, First Car Rental representatives hand over the brand new Toyota Quantum to Hestie Veitch, Head of CUADS.
Photo: Valentino Ndaba

The Centre for Universal Access and Disability Support (CUADS) launched successfully on 24 July 2015. The objective was “to make more people on campus and from the greater UFS community aware of the services that we provide, and to spread the word about Universal Access.”

“Since the center was founded in 2001, structural and systematic developments have occurred in order to create a welcoming and accessible learning environment that grants students opportunities to be successful in their academic endeavours. Thus, the Unit for Students with Disabilities (USD) has evolved into the CUADS in support of the social model of disability,” said Hetsie Veitch, former Head of the Centre.

Implementing the Universal Access and Universal Design approach has aligned the University of the Free State (UFS) with international standards.

Mingling with the experts

Vendors from across the country displayed their products, and offered demonstrations of functional gadgets and essentials at the event.

Marita Erlank from Sensory Solutions demonstrated how to operate the specialised scanner, which converts printed material to enlarged electronic text and audio, using the Open Book software.

Representing the university’s Sign Language Student Association were Carla Bester, Elrie de Toit and Tebogo Chabangu. To support Deaf Awareness Month (September), theyplan to dedicate a weekto facilitating free workshops for students not registered for the module.

David Greenland and his teamwere also present as part of a Wheelchair Appreciation Month campaign. On 1 September2015,the group of students will raise awareness of the daily challenges faced by mobility-impaired persons by spending the day in wheelchairs.

The day ended on a festive note, by courtesy of the First Car Hire Rental Company. A brand-new Toyota Quantum was handed over as a long-term rental, enabling students of the university to travel between campuses free of charge.

CUADS aims to continue transforming the UFS into a universally-accessible environment by collaborating with internal and external stakeholders. The launch marks a significant step towards Universal Access and Design.

 

 

 

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