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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Two research chairs awarded to UFS women
2015-09-15


Prof Pumla Gobodo-Madikizela

Two professors at the University of the Free State (UFS) have just been chosen as recipients of research chairs by the National Research Foundation’s South African Research Chair Initiative.

The research chairs are a massive financial injection for research in each of the relevant disciplines – that of Profs Pumla Gobodo-Madikizela from the Centre for Trauma, Forgiveness, and Reconciliation Studies at the UFS, and Felicity Burt from the Department of Medical Microbiology in the Faculty of Health Sciences.

Profs Gobodo-Madikizela and Burt are two of 42 female researchers in the country receiving research chairs as an initiative to give due recognition to women in research.

Profs Hendrik Swart, from our Departement of Physics and Melany Walker, Director, Centre for Research on Higher Education and Development, each also holds research chairs by the NRF. A third research chair has also been granted to the UFS Department of Plant Sciences for the research in field crops.


Prof Felicity Burt

The work of Prof Burt’s research chair is to investigate medically significant vector-borne and zoonotic viruses currently circulating; to define associations between these viruses and specific disease manifestations that have previously not been described in our region, to increase awareness of these pathogens; to further our understanding of host immune responses, which should facilitate development of novel treatments or vaccines and drug discovery.

Prof Gobodo-Madikizela, who has received international recognition for her work on forgiveness studies, will use this research chair to investigate historical trauma within two African contexts – those of South Africa and Rwanda. She hopes to gain insight into the role that memory plays in the formation of the experience of trauma, and to bring about healing of the trauma.

Prof Corli Witthuhn, Vice-Rector: Research at the UFS, expressed her pride on the announcement.

“We are extremely proud of the national recognition these two outstanding women researchers received.  The UFS strives for research excellence, and the five current NRF research chairs, as well as two NRF A-graded researchers who are at the forefront of their disciplines globally, indicates our continued commitment to innovating, relevant, and high-impact research.  We are excited about the progress of the past two years to position the UFS as a national leader in research.”

 

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