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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS hosts first ACS Institute held on African soil
2015-12-08



The first ever Association for Cultural Studies (ACS) Institute hosted on the African continent is taking place on the Bloemfontein Campus. At the event are, from the left: Prof Jonathan Jansen, Vice-Chancellor and Rector of the UFS; Prof Jean Comaroff, Alfred North Whitehead Professor of African and African-American Studies and Anthropology at Harvard University; Prof Helene Strauss, Chair of the Department of English at the UFS; and Prof Gil Rodman, Chair of the Association for Cultural Studies and Professor of Communication Studies at the University of Minnesota.
Photo: Johan Roux

The University of the Free State (UFS) is hosting the 2015 conference of the Association for Cultural Studies (ACS) Institute – the first time for this international event to take place on the African continent.

From 7 – 12 December 2015, some of the world’s leading scholars in cultural studies are taking part in the conference on the Bloemfontein Campus. The event has been organised by the UFS Department of English in collaboration with colleagues from other departments in the Faculty of the Humanities.

 The ACS is the foremost international association for scholars in cultural studies, and has been hosting the biennial Crossroads in Cultural Studies Conference since 2006. In 2011, the ACS held its inaugural institute at the University of Ghent (Belgium), followed, in 2013, by one at the Alpen-Adria University Klagenfurt (Austria). As the 2015 meeting of the institute is the first to be held in Africa, the organisers aim at highlighting the contributions that scholars from our continent and other (post)colonial contexts have made to cultural studies, even as it engaged many of the long-standing theoretical concerns generated for the field by scholars from the Global North.

Themed ‘Precarious Futures’, the conference explores how cultural studies might assist in charting more equitable futures by reflecting critically on the cultural, economic, and political trajectories within which precariousness – a state increasingly anticipated for the planet – might be altered. Experts in a diversity of disciplines are sharing their perspectives in the form of seminars and lectures.

Keynote lectures are delivered by Prof Jean Comaroff (Harvard University), Prof John Erni (Hong Kong Baptist University), Dr Jo Littler (City University London), Dr Zethu Matebeni (University of Cape Town), and Prof Handel Kashope Wright (University of British Columbia).

In her opening lecture on Monday 7 December 2015, Prof Comaroff addressed the challenging relationship of law, detection, and sovereignty in contemporary African polities within the South African post-apartheid context.

Topics discussed include climate change; the archives of everyday life; cross-racial intimacies; ethnography; meritocracy; cultural studies and human rights; China and globalisation; gender, sexuality, and race; and governance, embodiment and the work of care.

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