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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

UFS students should register like this
2004-12-15

Student activities on the main campus of the University of the Free State (UFS) will start next year when first-time entering first-year students will be welcomed by the Rector and Vice-Chancellor of the UFS, Prof Frederick Fourie, on 15 January at 11:00 in the Callie Human Centre on campus.

“The registration process will start on 17 January 2005 when first-time entering first-year students, who applied for admission before 30 November 2005, will start registering. These students may register until 21 January 2005 according to a programme,” said Mr Vernon Collett, Registrar: Academic Student Services at the UFS.

Senior undergraduate students may register from 22-29 January 2005 and postgraduate students, first-time entering first-year students and other students who applied for admission after 30 November 2004 until 15 January 2005, may register from 31 January- 4 February 2005 according to a programme.

According to Mr Collett postgraduate students who applied for admission from 15 January- 11 February 2005, may register according to a programme from 7-11 February 2005. Students who want to change their field of study or want to amend their modules, may do it during this period.

“To ensure an orderly registration process, strict adherence to the registration programme will be maintained,” said Mr Collett.

Applications for the Career Preparation Programme (CPP) close on 21 January 2005 en those for upgrading courses in Education, will close on 2 February 2005.

“Pipeline students from Vista must register on the UFS’s Vista campus on the dates already mentioned and first-year students from Vista must register on the UFS’s main campus,” said Mr Collett.

All registrations will take place daily from 08:00 in the Callie Human Centre on the main campus.

According to Mr Collett a variety of services will be available to students in the Callie Human Centre during the registration – among others advice on bursaries, loans, staff and council bursaries, enquiries for international students, information on class and room tables, student cards, vehicle permits etc.

At the Qwaqwa campus all first-time entering first-year students must report on 17 January 2005, after which the registration of these students will take place according to a specific programme. Application for admission to this campus close on 1 February 2005. First-time entering first-year students will be welcomed by the Rector and Vice-Chancellor of the UFS, Prof Frederick Fourie, on 22 January 2005 at 11:00 in the Nelson Mandela Hall on campus.

Lectures at the UFS’s main campus as well as the Vista- and Qwaqwa-campusses will commence on 31 January 2005.

Prospective students who want to apply or who have any enquiries can call (051) 401-3000 or visit the UFS web site late in December 2004 at www.uovs.ac.za.

A complete registration programme for first-time entering first-year students who registered before 30 November 2004 will appear in Volksblad of 29 Desember 2004.

      Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
15 December 2004

 

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