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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

SARChI Chair on disease resistance and quality in field crops awarded in UFS Department of Plant Science
2016-02-01

Description: SARChI Chair  Tags: SARChI Chair

Prof Labuschagne

A South African Research Chairs Initiative (SARChI) chair has been awarded in the Department of Plant Sciences at the University of the Free State (UFS). The chair will be headed by Prof Maryke Labuschagne, and will focus on crop quality breeding and disease resistance in field crops.

The disease resistance research by the chair will be headed by Prof Zakkie Pretorius. The disease resistance breeding will be a continuation of the internationally-acclaimed wheat rust research that Prof Pretorius has been conducting during his career.

The quality breeding will focus on crop protein quantity and quality as well as on iron, zinc, and beta carotene biofortification of staple crops such as wheat, maize, and cassava.

Prof Labuschagne believes that food security is one of the key factors for stability and prosperity on the continent. Her research and that of her students focuses on the genetic improvement of food security crops in Africa, including such staples as maize and cassava. “These crops are genetically improved for yield, drought tolerance, disease, and insect resistance, as well nutritional value,” she said.

Last year, one of  Prof Labuschagne’s PhD students, Bright Peprah, received an award for $473 000 from the competitive Program for Emerging Agricultural Research Leaders (PEARL) of the Bill and Melinda Gates Foundation for his project on improving the beta-carotene content in cassava.

Prof Labuschagne also received the prestigious ‘Continental Lifetime Achiever Award’ from Africa’s Most Influential Women in Business and Government Programme (MIW) last year for her commitment and continuous contributions to food security. She is an NRF-rated researcher, and author or co-author of over 160 articles in accredited journals.

Research Chairs have been designed by the Department of Science and Technology, together with the National Research Foundation, to attract and retain excellence in research and innovation at South African public universities. 

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