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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Rag teamwork leads to Armentum, Emily's float
2016-02-04

Description: Rag video screenshot Tags: Rag video screenshot
Rag video clip

Perhaps the residences Armentum and Emily Hobhouse were thrown into the deep end, but they still wanted to prove a point.

This is according to Hanko Minnaar, Residence Committee member for Rag at Armentum, shortly after the residences were announced as overall float winners of the University of the Free State (UFS).

According to Minnaar, Emily Hobhouse and Armentum overcame the challenge of building a float as a two-residence team, while most of the other hostels were in teams of three.

On 30 January 2016, after about two weeks of hard work and sweat, the residence twosome was named the winner at the Bloemfontein Campus.

“I am very proud. We couldn't have asked for more,” Minnaar said, after the residences Armentum and Emily Hobhouse celebrated their victory with house songs. “Anything is possible through teamwork.”

Tom and Jerry, Olaf and a Steri Stumpie

 The theme for this year was “Cartoons, Animation, and Children's Snacks”. Among other items, Armentum and Emily Hobhouse had Tom and Jerry, Olaf from Frozen, a Steri Stumpie, and a box of Astros on their float.

Description: Rag procession photo Tags: Rag procession photo

Photo: Charl Devenish

“We thought hard about what we wanted,” Minnaar said.

“We also asked some children, and they said that Tom and Jerry is a favourite, and Olaf has always been a winner as well. And Steri Stumpies, of course. Who doesn't like Steri Stumpies?” The residences Marjolein, Veritas, and Akasia were second overall, with Karee, Vergeet-My-Nie, and Sonnedou third.

Colourful processions

The events of the day started off with a morning procession from the Pelonomi Hospital to the Twin City Mall in Heidedal, where students and the community celebrated together, and meals were distributed.

The evening procession, from the Tempe robot in Nelson Mandela Drive to the Old Grey Sports Grounds, was greeted by hordes of spectators along the way.

Artists and Co captivate audience

In the evening, music lovers were entertained at Old Grey Sports Grounds by the legendary artists Vusi Mahlasela, the talented Karen Zoid, and an energetic Francois van Coke.

Local bands, Rise in Red and Simple Stories, added to the excitement. To top it all off, a special laser show made for a colourful visual bonus, coupled with great sound.

2016 Float results
Rag photo gallery

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