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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Leading African Studies scholar to represent UFS as research fellow at Leiden University
2016-03-10

Description: Dr Stephanie Cawood Tags: Dr Stephanie Cawood

Dr Stephanie Cawood to devote three months at the African Studies Centre Leiden as a visiting research fellow to further her research on the rhetorical imprint of Nelson Mandela.
Photo: Supplied

Dr Stephanie Cawood, Programme Director and Senior Lecturer at the University of the Free State (UFS) Centre for Africa Studies has been offered a visiting research fellowship to the African Studies Centre Leiden (ASCL) at Leiden University in the Netherlands. The ASCL is entirely devoted to the study of Africa transcending multiple faculties and is known for its extensive library.

As a visiting research fellow from April to June 2016, Dr Cawood looks forward to expanding her network as well as intellectual horizons with the broad spectrum of knowledge archived by the ASCL. “Working so closely with the scholars at the African Studies Centre Leiden will enrich my research and broaden my international footprint as a scholar,” Dr Cawood says.

Her research at ASCL follows on her doctoral research on the former president of South Africa, Nelson Mandela’s rhetorical imprint, and will explore the conceptual, cultural, ideological and historical influences that shaped the thought and rhetoric of Nelson Mandela. She is particularly interested in studying the intertextual dynamics in Mandela’s rhetoric with historical figures such as Jawarharlal Nehru, Martin Luther King Jr and Winston Churchill.

According to Dr Cawood, this research “will deepen the understanding of Nelson Mandela’s rhetorical journey from struggle to liberation and unpack the various influences that made him the political figure he ultimately became.”

During her tenure at Leiden University, Dr Cawood will prepare a manuscript to be published by the ASCL as a working paper and also present seminars.

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