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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Arts and Science collaborate in creating sustainable futures
2016-03-16

Description: Dr Keith Armstrong Tags: Dr Keith Armstrong

Creating a future where living green is the status quo: Dr Keith Armstrong
Photo: Lihlumelo Toyana

In creating partnerships across disciplines, mankind gains a deeper understanding of how to create the future. This is the premise upon which Dr Keith Armstrong bases his research and experimental art. Dr Armstrong is an Australian Hybrid Media artist and a Senior Research Fellow at Queensland University of Technology in Australia.

Artists that make things happen

“My journey has shifted from an artist that makes things to an artist that makes things happen,” he said at the New Futures: Innovations in Arts and Science public talk recently at Oliewenhuis Art Museum. The talk, organised by the Johannes Stegmann Art Gallery, was part of a series of artistic projects presented by the Programme for Innovation in Arts and Development (PIAD). This initiative is spearheaded by the UFS and Vrystaat Arts Festival, kindly supported by The Andrew W. Mellon Foundation.

Dr Angus Hervey – an Australian writer, technologist and science communicator– was also a speaker at the event. Dr Hervey is a co-founder of Future Crunch, a platform for intelligent, optimistic thinking about the future. He strongly shares Dr Armstrong’s passion and viewpoints.

Dr Armstrong’s work is motivated by social and ecological justice. His non-traditional research and more than 60 artworks serve to evoke audiences to create sustainable futures.

Building the future

Dr Armstrong is in the process of making “things happen” in informal settlements across the Free State by means of his Re-Future project. The project brings together sustainability, community development, and creative action. It moves away from conventional art practices and instead offer a platform to rethink and therefore re-future our practices of sustainability.

The Re-Future project has been initiated through a collaboration between the Johannes Stegmann Art Gallery, the UFS Centre for Development Support (CDS) and Qala Phelang Tala (QPT) and the Vrystaat Art Festival.

According to Anita Venter, a lecturer at CDS and founder of QPT, empowerment is at the centre of the artist-initiated, yet community-controlled project. “It gives a new direction and new hope to the community,” she said.

For more information
Angela de Jesus, dejesusav@ufs.ac.za or +27(0)51 401 2706

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