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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Prof Van den Oever gives students a different perspective
2016-05-06

Description: Prof Van den Oever gives students a different perspective Tags: Prof Van den Oever gives students a different perspective

Prof Annie van den Oever from the Netherlands presented a series of guest lectures on media technologies to students of the Film and Visual Media Programme at the University of the Free State (UFS). Here from left is Chris Vorster, lecturer in Drama and Theatre Arts, Prof Van den Oever, and Dr Pieter Venter, Senior lecturer at Drama and Theatre Arts.
Photo: Jóhann Thormählen

She played a part in conceptualising the Film and Visual Media Programme at the University of the Free State (UFS), and sees film from a perspective different from most young South Africans.

According to Chris Vorster, lecturer of the UFS BA Honours degree in Film and Visual Media, this is one of the reasons why Prof Annie van den Oever’s visit is of such great value. The actor, who is a lecturer in Drama and Theatre Arts, believes it is important to expose his students to influences outside their normal experience.

Prof Van den Oever, an extraordinary professor at the UFS since 2011, presented a series of guest lectures on media technologies from 11-14 April 2016 at the Audio Visual Studio on the Bloemfontein Campus. She is a senior researcher for Film at the University of Groningen in the Netherlands, and an Associated Researcher for Film at Paris 1, Panthéon Sorbonne, in France.

Another milieu

“It is invaluable for students, in any field of study, to receive as many influences from the outside. Therefore, it is important to have someone here from another milieu and context. And academically, she is outstanding,” says Vorster.

Vorster’s students are also exposed to practical expertise from the industry in the country, not only academics.

Relationship with UFS

Prof Van den Oever says she usually visits the UFS twice a year. Her recent lecture series on media technologies was about the power of visual and film culture today, and how you can understand its powers. “Why strange effects work strongly and why the strange is inserted, because people respond strongly to them,” she says.

Prof van den Oever enjoys meeting new people, and often works with colleagues from the UFS on various projects. She also is full of praise for the management of the university. “It is great to work across cultures, and be part of a university in transition.”

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