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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

German Ambassador speaks on universities as agents for transformation
2016-05-25

Description: German Ambassador speaks on universities  Tags: German Ambassador speaks on universities

Eva Ziegert, JC van der Merwe, Lindokuhle Ntuli, Anita Ohl-Meyer, Ambassador Walter Lindner, Tali Nates, and Prof Leon Wessels at the dialogue session hosted by the IRSJ
Photo: Johan Roux

“Change is facilitated through education, not by means of radicalism, violence, or revolution.” Speaking at the Bloemfontein Campus of the University of the Free State (UFS) on Thursday 12 May 2016, the German Ambassador, Walter Lindner, urged students to engage in profitable dialogue instead, keeping their values and ideals in mind while changing the system from the inside.

The Institute for Reconciliation and Social Justice (IRSJ) hosted a full day of dialogues and discussions, the highlight of which was a critical dialogue with Ambassador Lindner, entitled “Universities as agents of transformation in society—Germany’s experience with the student protests of the 1968 movement and the difficulties it has reconciling with its past.” This was followed by a student colloquium, hosted by the Student Representative Council, which concluded with the second in the Africa’s Many Liberations seminar series, co-hosted by the IRSJ and the International Studies Group (ISG), with the title of “Fanon and the relevance of personal and collective decolonisation in today’s South Africa”.

Mr Lindner related his experience of student protests in Germany during the late 1960s, drawing certain parallels with South Africa’s own recent protests. According to Ambassador Lindner, it is “the impatient youth that drives forward change”, but cautioned against radicalism as a long-term solution.

Pointing out the various challenges facing humankind today, such as the lack of natural resources, unbridled climate change, and population growth, Mr Lindner stated that politicians (and the youth of today) would do well to focus on these greater issues, rather than focusing on the more mundane issues with which they are faced on a day-to-day basis.

The subsequent dialogue session was facilitated by Tali Nates, Director of the Johannesburg Holocaust and Genocide Centre. A diverse array of questions and comments, both radical and more conservative, was directed at the ambassador, which he handled with unflappable aplomb.

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