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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Beauty personified through written word
2016-07-29

Description: Zubeida Jaffer Tags: Zubeida Jaffer

Dr Thozama April, University of Fort Hare
historian, Zubeida Jaffer, current Writer-in-Residence
in the Department of Communication Sciences
at the UFS and author of Beauty of the Heart:
The life and times of Charlotte Mannya Maxeke
and Prof Jonathan Jansen, Vice-Chancellor and Rector
of the UFS at the book launch of Zubeida Jaffer.
Photo: Rulanzen Martin

“It is quite easy to write a book in a professional capacity but very difficult to write a book from the heart.”

These were the words of Prof Jonathan Jansen, Vice-Chancellor and Rector of the University of the Free State (UFS), at the launch of Beauty of the Heart: The life and times of Charlotte Mannya Maxeke by Zubeida Jaffer, the current Writer-in-Residence in the Department of Communication Sciences at the UFS.

Perseverance and dedication yields results

Writing a book from the heart is exactly what Jaffer, an award-winning South African journalist and author, set out to do. “When you make the choice to write a story, you need to be very dedicated,” she said.

As this is Jaffer’s third book, one would think that she would have no difficulty in putting pen to paper. On the contrary, she mentioned that it was, in fact, the hardest book she has written because the narrative was not easy to get hold of.

“I wanted Charlotte’s voice to come through, and it took my team and I three years of research and writing,” she said.

Maxeke’s story helps to shape South African society

The three-person panel, hosted by the UFS Sasol Library and SUN MeDIA, and chaired by Prof Jansen, included Jaffer and Dr Thozama April, University of Fort Hare historian who had done her PHD thesis on Maxeke.

Dr April said that Maxeke’s life story is an inspiring one, as it encourages a rethinking of established narratives. “These established narratives have made it possible for historians and researchers to write about the shaping of South African society,” she said.

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