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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Beauty from UFS a national Miss Earth finalist
2016-08-19

Description: Elnè van Coller Tags: Elnè van Coller

Elnè van Coller, final-year
Occupational Therapy student at
the University of the Free State
was selected as a national
finalist in Miss Earth South Africa
(SA) leadership programme on
1 August 2016.
Photo: Miss Earth SA

“Greening my community and touching lives is my purpose in life. We were put on this beautiful Earth to serve others and make a difference in the world.”

This is what Elnè van Coller, final-year Occupational Therapy student at the University of the Free State, had to say after being selected as a national finalist in Miss Earth South Africa (SA) leadership programme.

She has set out to be the change. Not only does she want to see change in her own community but in the rest of the world. The reason she entered the Miss Earth SA programme is to inspire others.

Leadership programme to inspire others

The Miss Earth SA is a leadership programme which aims at empowering young South African women with the knowledge and platform to create a sustainable difference. It helps create awareness of sustainable development, the environment, wildlife, and the conservation of the natural legacy.

 “Miss Earth SA is an amazing platform for me to develop leadership skills, raise awareness, and be actively involved in environmental affairs as well as serving the community,” said Elnè.

Getting the community involved is important

The theme for this year’s Miss Earth SA programme is Waste Stops With ME, so clean-ups are a major part of the programme. Elnè started a Facebook page, Team Up-To-Clean-Up Bloemfontein. “This page is to share environmental facts, inform the people of Bloemfontein about the clean-ups, as well as get them involved”.

The Miss Earth SA gala week will take place in Johannesburg from 5 – 9 September 2016 when the Miss Earth SA 2016 will be announced.

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