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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Soetdoring, Armentum crowned 2016 serenade champions
2016-08-22

Description: Soetdoring Serenade Singoff  Tags: Soetdoring Serenade Singoff

Armentum were crowned as this year’s winners for
the male residences. The ladies from Soetdoring
walked away with the winner’s title for the female
residences.
Photo: Johan Roux

“We made history this year! This is the first time that Armentum has ever won the Serenade competition”. These were the words from Danie Serfontein, RC Culture from Armentum, after being crowned as this year’s Serenade Singoff champions for the male residences at the University of the Free State.

Soetdoring knocked out the competition from the other female residences to take home the crown. “It’s been one year of planning and almost five months of practice. The competition was very tough, but the girls really wanted to win this year,” said Elmarie Spangenberg, Soetdoring RC Culture.

This year’s Kovsie Serenade Singoff competition, one of the highlights on the Bloemfontein calendar, was characterised by fierce competition, top-class entertainment, and loads of singing talent. Spectators could follow the action from two venues on the Bloemfontein Campus, with participants performing at the Odeion and the Kovsie Church. Following passionate performances during rotations on 10 and 11 August 2016, the winners were crowned on Saturday 13 August 2016.

This year, there were five male residences and seven female residences competing for the chance to be crowned the Serenade Singoff champions for 2016.

The top three spots for the female residences:
• Soetdoring (1st)
• Marjolein (2nd)
• Kagiso (3rd)

The top three spots for the men’s residences:
• Armentum (1st)
• Veritas (2nd)
• Legatum (3rd)

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