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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Innovation the focus of 28th Sophia Gray Memorial Lecture
2016-09-06

Description: Stratford furniture design Tags: Stratford furniture design

Stratford never lost his passion for designing
furniture. Pictured here is some of his furniture
exhibited at the Oliewenhuis Art Museum.
Photo: Francois van Vuuren: iFlair Photography

Al Stratford, designer, inventor and architect, presented the 28th Sophia Gray Memorial Lecture on 25 August at the Reservoir at the Oliewenhuis Art Museum in Bloemfontein. The event, hosted by the Department of Architecture at the University of the Free State, was also the opening of an exhibition of Stratford’s work.

In his career of 40 years, Stratford has patented many products and won several awards in industrial design and architecture. He is known in South Africa for his development of innovative building technology such as the Winblok Precast Concrete Window System. In 2009 and 2010, he also served as president of the South African Institute of Architects.

The title of his lecture was: Reductive Innovation in Architecture. Throughout his career, Stratford endeavoured – through his designs and inventions – to apply the principle of “reduction” to the building material he used and technology he examined.

Stratford designs and builds smart buildings
Stratford says a home is the paradigm of self-expression. His career as architect started with the building of five houses in Gonubie, near East London. Everything he knew about architecture at that stage, he had taught himself by reading on the subject at the local library. Later on, he achieved great heights in his career by designing and building, among others, the Stratford Guesthouse; the sustainable and resourcefully designed campus buildings for the University of Fort Hare (an institutional building not utilising any electrical air-conditioning); the Edenvale Baptist Church; and a community hall.

His technology is widely used in the building industry

“The arrogance in me gets humiliated when I
see what other people and God has done.”


His technical drawing skills, acquired at an early age during his training as motor mechanic, are still practised years later, particularly in his inventions. Stratford is the inventor of technology commonly used in the building industry today. Of these, the Winblok window system which he patented in 1981, is one of his best known patents. The use of these windows is characteristic of many of the buildings he designed and built. Other technology he invented and patented, includes the Winstep stairs, the Windeck flooring system, and the StratFlex furniture technology.

Furniture designs win him awards
He likes to quote architect Ludwig Mies van der Rohe: “A chair is a very difficult object. A skyscraper is easier.” Stratford started designing and manufacturing his own furniture and never lost this passion. In 2013, he won the Innovation Award at the Design Indaba for his “flat pack” furniture technology.

The humble Stratford – designer, inventor, industrialist, and architect – says he is simply playing around with God’s creation. “The arrogance in me gets humiliated when I see what other people and God has done.”

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