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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Minister praises MUCPP initiative
2004-10-04

The Minister of Labour, Mr MMS Mdladlana, singled out the Mangaung University of the Free State Community Partnership Programme (MUCPP) for high praise during a conference at the MUCPP complex on 30 September 2004 .

“I am very pleased with what the partnership of different stakeholders can do and I thank all stakeholders for contributing to this initiative. This is the kind of energy that our country needs,” the minister told delegates to the conference.

He said the MUCPP was a very unusual and important partnership that is related directly to the mandate of government and supports two strategic objectives of government, namely halving poverty and halving unemployment.

The MUCPP was launched in 1991 as a partnership between the University of the Free State , the local community of Mangaung, local and provincial government and the private sector, in an effort to develop skills and contribute to fighting poverty.

Some of the existing projects of the MUCPP include:

  • Health centre (including a 24-hour maternity ward)
  • Dairy producing yoghurt and amasi
  • Sewing and knitting project
  • Indigenous food production (Tsa se tso)
  • Bakery
  • Bed and Breakfast accommodation
  • Etsa phapang (a hydroponic facility growing various vegetables)
  • Welding project
  • Low cost housing project
  • Sport and recreation facilities and programmes

According to the Minister, hundreds of young people, adult learners and people with disabilities have benefited from training and skills development and have become involved in carpentry, welding, painting, cleaning services, gardening and HIV / AIDS awareness programmes.

Minister Mdladlana said he was pleased that through partnerships with several Sector Education and Training Authorities (SETAs) which fall under the Department of Labour, the MUCPP could access hundreds of thousands of rands for such training and development.

“I can just salute those that have made it possible, and to encourage you to keep up the good work,” the minister said.

The MUCPP also provides a means for students of the UFS to render community service. The UFS was one of the first universities in South Africa to adopt a comprehensive community service policy in 2002. In terms of the policy, community service is integrated into curricula through service learning modules.

It is therefore of great importance that the UFS should support community sites such as the MUCPP where a holistic and integrated approach to mutual and reciprocal development of all partners is followed.

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