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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

PSP rejuvenating the South African professoriate
2016-10-25

Description: Dr Olihile Sebolai  Tags: Dr Olihile Sebolai

Dr Olihile Sebolai (Microbiology) is
one of two Fulbright scholars the
UFS Prestige Scholars’ Programme
has produced. He was a Fulbright
scholar at the University of Missouri
(Kansas City) and before that
conducted work at the University
of Birmingham in the UK.
Photo: Anja Aucamp

Twenty years. That is the difference between the average age of a UFS Prestige Scholar (35) and the average age of a South African academic (55). Since its inception in 2011, the UFS’s Prestige Scholars’ Programme (PSP) has pro-actively addressed the ageing profile of academia and the need to transform the social composition of the South African academy. In doing so it has generated more than R67 million in research funding, including R10 million in student and post-doctoral funding.

The programme seeks to identify, cultivate and promote outstanding scholarship among “young” members of the UFS academic staff – those who have acquired a doctorate within the last five years. It provides support (funding applications, report writing, etc.) and helps with international placements in order to accelerate the establishment of an international footprint in expectation of the participants’ entry into the professoriate.

The programme mentors scholars from five faculties at the UFS. PSP scholars have conducted research and established collaborations in North America, Europe and Japan at institutions such as Harvard, UCLA, Cornell University, University of Michigan, University of Missouri, University of British Columbia, Oxford University, Cambridge University, University of Manchester, University of Birmingham, Basel University, University of Bologna, Leiden University, Uppsala University, Okinawa Institute of Science & Technology and Obihiro University of Agriculture and Veterinary Medicine.

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