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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Valour inspires book on community protests
2016-10-18

Description: Dr Matebesi book cover Tags: Dr Matebesi book cover

The cover of Dr Sethulego Matebesi’s
book, Civil strife against local governance:
Dynamics of community protests in
contemporary South Africa, that will be
released on 1 November 2016.
Photo: Supplied

Two significant political events: the murder of an unarmed protester, and school children forced out of school sparked the idea to write a book on community protests.
The book, Civil strife against local governance: Dynamics of community protests in contemporary South Africa, by Dr Sethulego Matebesi, gives an academic account of service delivery protests in South Africa.

Research address protests in different communities
“The focus of my book is on community protests directed against municipalities in both predominantly black and white communities,” Dr Matebesi, senior lecturer in the Department of Sociology at the University of the Free State, said. The funding for the book was received from the National Research Foundation and the Erasmus Mundus EU-Saturn Scholarship.

Informs literature on service delivery protests

The struggle against municipalities reaches across geographic and demographic boundaries, but the violent turn of protests in black communities in contrast to white communities has become somewhat of a hegemonic account by scholars. “The book connects the critical issue of community protests with the equally precarious issue of political trust in local government,” Dr Matebesi said. Case studies in the book are indicative of significant shifts in community protest – thus making it timely. Dr Matebesi said: “The book informs the growing literature on community protests and also fills an empirical void by including protesters in residents’ associations.”

“The book is a personal milestone and
the single greatest return on the
sacrifices made over the past 4 years.”





Personal milestone worth the sacrifice
Research was conducted between 2012 and 2015, whereby two case study sites were selected in four provinces to account the different tactics used. “The book is a personal milestone and the single greatest return on the sacrifices made over the past four years,” Dr Matebesi said.

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