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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

A guide and a friend
2016-12-12

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Louzanne Coetzee and Khothatso Mokone.
Photo: Charl Devenish

Behind every successful Paralympic athlete is a guide, and behind blind athlete Louzanne Coetzee is none other than former Kovsie student Khothatso Mokone.

Mokone, who is a sports journalist and freelance photographer, says he is not entirely sure that his busy schedule is very balanced, but he tries to ensure he squeezes as much as possible into his day. One thing he always makes time for is his training. “As a young person, I try to take every opportunity that comes my way,” he says.

This young runner, who has been Coetzee’s guide for the past eight months, says that every race they have run together thus far has always been better than the last. “The partnership grows harmoniously every day. We talk about almost everything there is, not only running,” Mokone says.

Mokone guided Coetzee in the 1 500m of the Paralympics in Rio de Janeiro in September this year when she was disqualified. 

Mokone, who loves comedy and Dubai, is inspired by SAfm journalist and presenter Ashraf Garda. “He talks a lot about current issues that affect our country and I like his style of presenting. He is a good orator.”

Something people may not know about him is that he always walks around hopeful that the best is yet to come. “When I walk down the street, I walk with confidence and people think I have made it in life not knowing that I only have hope for a better tomorrow,” he says.

Although he is not yet as successful as he would like to be, Mokone encourages the youth to “open their eyes and ears to set realistic goals and work with patience to achieve each goal, whether short or long term”.

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