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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

UFS researcher fills void in South African policing history
2017-01-02

Description: Dr Cornelis Muller Tags: Dr Cornelis Muller 

Currently a Postdoctoral fellow in the International
Studies Group, Dr Cornelis Muller’s PhD thesis explores
late nineteenth century South African policing on the
Witwatersrand.
Photo: Rulanzen Martin

“I used policing on the Witwatersrand as a lens through which to examine aspects relating to state formation within the South African Republic.”

This is how Dr Cornelis Muller, a postdoctoral fellow in the International Studies Group at the University of the Free State (UFS), described his PhD thesis called Policing the Witwatersrand: A history of the South African Republic Police, 1886-1899. The thesis fills an empirical void in the history of settler colonial policing in South Africa.

His research was also featured in the South African Historical Journal, which is published by Routledge. Dr Muller received his PhD from the UFS during the 2016 Winter Graduation ceremonies. He received a scholarship from the university to conduct his three-year research.

Relationship between police and state examined

The study presents itself as an institutional biography in which the relationship between the South African Republic Police (known as the Zarps), the state, and broader society are examined. The period under investigation was a time when political, economic, and social complexities on the Witwatersrand created tension between South Africa and Great Britain.

An important theme throughout the thesis is the relationship between the police, the mining industry, and the so-called Uitlander community. Crime was also an important contributing factor to the complex relationship that developed between the Zarps and the policed in Johannesburg’s formative years.

“Johannesburg was a town under siege by a variety of crimes which ranged from vagrancy, drunkenness, gambling, and prostitution to robbery, murder, and assault,” said Dr Muller.

Archives in South Africa and Great Britain consulted
“My thesis follows a chronological approach in which various themes accounting for the development of the police on the Witwatersrand are highlighted.” Framed within the bureaucratic and administrative functioning of the Zarps, he examined aspects relating to crime, crisis, and conflict between the police and society. The thesis also details the relationship between the police and Johannesburg’s black community.

As with any historical research, it comprised internal and external source criticism and content analyses of a wide range of archival records.

Dr Muller had the opportunity to visit several archives and libraries in South Africa and Great Britain. “Some of the more important archival collections were assessed at the National Archives in Pretoria.” These included the Archive of the State Attorney and the Archive of the Magisterial District of Johannesburg.

“My study thus adds to scholarship that seeks to provide a more nuanced understanding of the South African Republic’s administrative functioning and internal politics in the late nineteenth century,” concluded Dr Muller.

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