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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Top achievers arrive at UFS
2017-01-26

Description: Tshepo Thajane Tags: Tshepo Thajane

Tshepo Thajane, winner of the Kovsies
Star of Stars competition.
Photo: Eugene Seegers

Although first-year registration officially started on 23 January 2017 at the University of the Free State (UFS), the Marketing department invited some of the top-achieving matrics in the country to an event on Friday 20 January to assist them with early registration. These high-flying pupils have AP scores of 40 and above, and worked hard to get to where they are today, with driving ambition for their future.

The #StarOfStars
Tshepo ”Doctor” Thajane is the winner of the newly-established Kovsies Star of Stars competition, and as such received a full bursary from the UFS, among other sponsorships. He has enrolled in Actuarial Sciences and will be housed at the Karee residence. When asked what drew him to our university, he responds: “I just loved the university before I entered it, and I chose the UFS because of the respect I was shown.”

Friendly reception
Lendl Ontong will be pursuing his LLB in the Faculty of Law, and has obtained a place in the brotherhood of the Karee residence. The Ontong family hails from Worcester in the Western Cape. Lendl’s father, Mr Lionel Ontong, had this to say of his experience: “The staff at the UFS, especially at the admissions office, is the friendliest group of people I’ve ever come across, and helpful as well. My wife was sceptical when I told her about the friendly treatment I experienced when I phoned the university, but when she witnessed it today, she could see it first-hand. The friendliness is contagious, and even though I’m tired after the long journey, their attitude has rubbed off on me. And my wife now has the assurance that her child is going to be happy here. The atmosphere is one of homeliness. It’s fantastic! Even the netball coach introduced herself to my son and invited him to pop in for a cup of tea, and she won’t even be involved with his university journey. It meant a lot to us as parents.”

Description: Jani Gerber  Tags: Jani Gerber

Jani Gerber and her dad Jaco Gerber.
Photo: Eugene Seegers

Runs in the family

Jani Gerber is a second-generation Kovsie who hails from Port Elizabeth. She won the cultural division in the Matriculant of the Year competition in 2016 and was invited to join the UFS. According to her, she “didn’t even consider another university”.

Her dad, Mr Jaco Gerber, says: “The whole process of application and registration was very efficient and professional. Jani’s older sister, Anri, completed her MBChB at UFS last year and is currently working at the Pelonomi Regional Hospital. Jani has already been adopted by new friends in her residence. She says, “Some charming students welcomed us at the residence, and even helped out when we were unpacking.” Jani has aspirations to sing in the annual Stagedoor and Serenade Singoff competitions.

We welcome all our first-years and look forward to supporting them throughout their university journey!

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