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19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.
The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com. 

News Archive

Boyden observatory celebrates its achievements
2004-10-05

The red carpet will be rolled out and champagne glasses filled tonight when the Boyden Observatory outside Bloemfontein will launch the first phase of the new science centre.

This phase, which was completed earlier this year, consists of a new auditorium, reception area and paths which connect educational visiting points on the Boyden terrain.

“Over the past two years the Boyden Observatory has been re-sited as a research, educational and public facility. The new facilities are now being utilised for educational and public programmes. The 1,5m Boyden telescope has also recently been upgraded and is used for research purposes,” says Dr Matie Hoffman from the University of the Free State’s (UFS) Department of Physics, who is responsible for the management of the centre.

“The Boyden Observatory is a unique facility of the UFS - we are one of the few universities in the world who has its own observatory,” says Dr Hoffman.

“The main purpose of the science centre is to create enthusiasm for science amongst the public. The centre also has a great educational function and focuses specifically on the improvement of the quality of science education in the Free State,” says Dr Hoffman.

Fund-raising for the planned second phase of the science centre, which will consist of interactive in- and outside exhibition areas, will also start tonight. “After the completion of the second phase the Boyden Observatory will probably become the most accessible and public-friendly observatory in the country and a great asset for the Free State Province,” says Dr Hoffman.

A small robotic telescope, which will be controlled from the University College Dublin in Ireland, will also be installed at the Boyden Observatory this year.

“Just as this year is a significant one for the UFS with its centenary celebrations, so it is also a significant one for the Boyden Observatory. The Harvard University in the United States of America started with the construction of the original 1,5 m telescope in its original form 100 years ago, the telescope was put in place at Boyden 70 years ago and Mr Uriah Boyden – the person who donated the money with which the Boyden Observatory was constructed, was born 200 years ago,” says Dr Hoffman.

The first phase of the science centre was built with funds sponsored by the AngloGold Fund, the Shuttleworth Foundation, the Charl van der Merwe Trust and the Lila Theron Trust. Donations from the Friends of Boyden Observatory and other individuals also contributed to the success of the project.

Those who are interested in educational tours of the science centre can contact Dr Hoffman at (051) 401-2322.

Media release
Issued by: Lacea Loader
Media Representative
Tel: (051) 401-2584
Cell: 083 645 2454
E-mail: loaderl.stg@mail.uovs.ac.za
5 October 2004

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