Latest News Archive

Please select Category, Year, and then Month to display items
Previous Archive
19 July 2021 | Story Lunga Luthuli | Photo Supplied
Fletcher Hiten, Chief Bioanalyst at FARMOVS, next to Aurora.

The Bioanalytical Services Division (BASD) at FARMOVS comprises a group of skilled and passionate scientists involved in the quantification of drugs, metabolites, and biomarkers in various biological matrices. One of their Analytical Science experts, Fletcher Hiten, explains what sets their team apart from the rest.

“Over the past 47 years, we have developed almost 600 validated assay methods. Most of these methods are for the analysis of ‘small’ molecules using chromatographic techniques such as LC-MS/MS, GC-MS, and HPLC, although LC-MS/MS is the technique of choice. New bioanalytical assays are continuously being development and validated in adherence to international regulatory guidelines set by the US-FDA and European Medicines Agency (EMA),” says Hiten.

“Recently, we decided to enhance our capabilities by recruiting exceptional talent. The newest member of the FARMOVS team is Aurora, a SCIEX Triple Quad™ 7500 LC-MS/MS mass analyser. Aurora is Latin for ‘dawn’: the beginning of a new era, especially one considered favourable. The SCIEX 7500 is currently marketed as the most sensitive triple quadrupole mass spectrometer available, allowing for sub-picogram/ml quantification. This means that Aurora will set FARMOVS apart from other clinical research organisations (CROs), creating an exciting and favourable landscape for clients to explore new partners in research.” 

Hiten stated: “If there was ever a time to move your next study to FARMOVS, it is now. To have Aurora on our team has many advantages, given that our clients can access unprecedented analytical sensitivity, which enables the quantification of pharmacokinetic (PK) profiles of drugs that have very low systemic absorption. These include predominantly local acting drugs, such as plasma concentrations of respiratory drugs (e.g., tiotropium and ipratropium), topically applied creams and ointments, and ophthalmology drops with ultra-sensitivity.”

“In addition, the quantification of drugs in low-volume matrices will also be exponentially enhanced, enabling the quantification of body fluids, where only a few microlitres can be collected, for example vaginal fluid, dried blood spots, cerebrospinal fluid, aqueous humour, synovial fluid, and epidermal micro-dialysis lysate – to name a few. The quantification of absorbed exogenous drugs into tissue, like vaginal biopsies and hair follicles, is also possible,” added Hiten. 

“And finally, multiple analyte analysis. In this case, the collected blood sample needs to be split into multiple aliquots for analysis, for example drug-drug interaction (DDI) studies with the Basel cocktail. The smaller sample volumes will allow more frequent sampling to be feasible and thus more accurate DDI interpretation,” Hiten explains.

“As a bio-analyst, one is seldom surprised. However, Aurora has already opened doors to new frontiers for our entire team and we cannot wait to do some more exploration,” says Hiten. 

To find out more about what Aurora and the FARMOVS team can do for your study, email business@farmovs.com

News Archive

Suspect in theft of computer equipment arrested
2007-11-16

A suspect, who may be involved in the recent theft of computer equipment from buildings on the Bloemfontein campus of the University of the Free State (UFS), has been arrested.

On 13 November 2007 an alarm in the Agriculture Building on the Main Campus of the UFS was activated. Protection Services reacted to the alarm and the person, who tried to run away, was pursued and later arrested.

The suspect was handed to the South African Police Service (SAPS). Currently SAPS is conducting an intensive investigation in co-operation with Protection Services at the UFS.

“The extent of the investigation goes beyond this single case for which the captive was arrested,” said Mr Willie Frankim, Manager: Protection Services at the UFS.

Meanwhile, the UFS’s Safety Committee has decided on a number of measures to heighten security on campus, including:

  • Patrols between buildings are to be intensified.
  • Vehicles leaving the campus will be searched. This is being done on an ad hoc basis at all the gates.

According to Mr Frankim the university is also looking at extending the alarm system and measures to secure buildings on campus.
He said: “The above will not happen overnight. We request all staff members and students to give their co-operation and to be more security conscious by:

  • Giving their co-operation at the gates when their vehicle is searched,
  • To ensure that the windows of your office and building are closed,
  • To lock office doors when you leave the office, even if it is for a short while,
  • Not to leave your office unattended when there are strangers,
  • to report suspicious persons as soon as possible to Protection Services,
  • To ensure that valuable articles (laptops and cell phones) are locked away,
  • To ensure the safekeeping of keys (not in drawers or on top of a door frame), and
  • Determine who has access to a building and question anybody unknown.”

Contact Protection Services at any of the following numbers:

Duty room: O51-4012634 / 051-4012911

Mr Aggrey Litseho (investigation officer): 051-4013225 / 0836347919 /
Short cell phone x6060

Mr Willie Frankim (manager): 051 401 3438 / 0828831760/
Short cell phone x6000

“We can only combat crime if everybody is aware of their environment, everybody adheres to the basic rules and co-operates with Protection Services,” said Mr Frankim.

Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
15 November 2007
 

We use cookies to make interactions with our websites and services easy and meaningful. To better understand how they are used, read more about the UFS cookie policy. By continuing to use this site you are giving us your consent to do this.

Accept