Prof Koos Albertyn
Position
Professor
Department
Microbial Biochemical and Food Biotechnology
Address
BTG C102
Biotechnology
IB 61
RC784
Telephone
051 401 2223
Office
C101
Information

Short CV

 

After completing my Ph.D. in 1996 I completed a Post-doctoral study at Rice University, Houston, USA to investigate the effect of pressure sensing mechanisms in micro-organisms. This project was a NASA funded project related to the study of bone mass decrease experienced by astronauts especially with long term exposure to zero gravity under the supervision of Prof. M. Gustin. After my return to South Africa I was appointed as lecturer in 1999 at the UFS and currently my research focus on the use of yeast as host for heterologous expression, which also includes the taxonomic and biotechnological potential of yeasts. The latter formed part of a NRF SANBI (South African National Biodiversity Institute) funded project regarding yeast biodiversity [NRF SANBI grant].  This project had a specific focus on identifying yeasts, including possible pathogens, from the environment. This lead to the establishment of a research grouping formally established in 2014 called The Pathogenic Yeast Research Group consisting of three PI’s (Prof. CH Pohl, Dr. O. Sebolai and myself). This brought together three principle investigators with knowledge regarding various virulence factors (including immunomodulatory metabolites) produced by the Candida and Cryptococcus as well as molecular biology of yeasts. The research conducted in this research group culminated in the awarding of a NRF SARChI research chair in pathogenic Prof. CH Pohl-Albertyn in 2019.


Publications


Publications (Short List)

PATENTS

  • Sebolai, O.M., Ogundeji, A.O., Albertyn, J., Pohl, C.H. & Kock, J.L.F. (2013). Method for the identification of clinical Cryptococcus neoformans and Cryptococcus gattii isolates. PA158794P. South Africa (CIPC).
  • Albertyn J, Labuschagne M. Theron C. & Smit MS. (2011). Novel expression constructs. Patent number 2011/04652. Filed 23 June 2011.
  • Smit MS, Labuschagne M, Albertyn J, van Rooyen, N & Maseme, J. (2011). Expression Construct for the Co-expression of Vanillyl Alcohol Oxidase Encoding Genes. Patent number 2010/06445 Filed 2 September 2011.
 

CHAPTERS IN BOOKS

  • Albertyn J, Pohl CH and Viljoen BC. (2014). Rhodotorula. Encyclopaedia of Food Microbiology, 2nd Ed. In Print.
  • F. Thevenieau, A. Beopoulos, T. Desfougeres,  J. Sabirova, K (J). Albertyn, S. Zinjarde and J-M. Nicaud (2010). Uptake and assimilation of hydrophobic substrates by the oleaginous yeast Yarrowia Lipolytica (Volume 2, Part 6, Chapter 38, p. 1513-1527). In: Handbook of Hydrocarbon and Lipid Microbiology. Ed. K.N. Timmis, Section Eds. T. McGenity, J.R. Van der Meer, V. de Lorenzo. ISBN: 978-3-540-77588-1.
  • Nel, S. Labuschagne M. and Albertyn J. (2009). Yeasts as eukaryotic expression systems. In: Diversity and Potential Biotechnological Applications of Yeasts. Eds: T. Satyanarayana and G. Kunze. ISBN: 978-1-4020-8291-7. Springe Science and Business Media, the Netherlands.

PUBLICATIONS

  • du Plooy, L. M., Sebolai, O. M., Pohl, C. H., & Albertyn, J. (2018). Functional Characterization of Cryptococcal Genes: Then and Now. Frontiers in Microbiology, 9(September), 1–9. Impact factor: 4.019

     

  • Fourie, R., Kuloyo, O. O., Mochochoko, B. M., Albertyn, J., & Pohl, C. H. (2018). Iron at the Centre of Candida albicans Interactions. Frontiers in Cellular and Infection Microbiology, 8(June), 1–14. Impact factor: 3.520

     

  • Motaung, T. E., Ells, R., Pohl, C. H., Albertyn, J. & Tsilo, T. J. (2017). Genome-wide functional analysis in Candida albicans. Virulence 8(8), 1563–1579. Impact Factor: 5.418

     

  • Madu UL, Ogundeji AO, Pohl CH, Albertyn J and Sebolai OM (2017) Elucidation of the role of 3-hydroxy fatty acids in Cryptococcus-amoeba interactions. Frontiers in Microbiology. 8:765. doi:10.3389/fmicb.2017.00765. Impact factor: 4.019

     

  • R Fourie, R Ells, G. Kemp, OM Sebolai, J Albertyn, CH Pohl (2017) Pseudomonas aeruginosa produces aspirin insensitive eicosanoids and contributes to the eicosanoid profile of polymicrobial biofilms with Candida albicans. Prostaglandins, Leukotrienes and Essential Fatty Acids 117: 36–46. Impact factor 2.437

     

  • R Fourie, R Ells, CW Swart, OM Sebolai, J Albertyn, CH Pohl (2016). Candida albicans and Pseudomonas aeruginosa interaction, with focus on the role of eicosanoids. Frontiers in Physiology 7. Impact factor 3.394

     

  • Osopale, B.A., Witthuhn, C.R., Albertyn, J. and Oguntoyinbo, F.A. (2016). Culture dependent and independent genomic identification of Alicyclobacillus species in contaminated commercial fruit juices. Food Microbiology, 56, pp. 21-28. Impact factor 4.090

     

  • AO Ogundeji, J Albertyn, CH Pohl, OM Sebolai (2015). Method for identification of Cryptococcus neoformans and Cryptococcus gattii useful in resource-limited settings. Journal of clinical pathology, jclinpath-2014-202790. Impact factor 2.914

     

  • Borgonie, G., Linage-Alvarez, B., Ojo, A.O., Mundle, S.O.C., Freese, L.B., Van Rooyen, C., Kuloyo, O., Albertyn, J., Pohl, C., Cason, E.D., Vermeulen, J., Pienaar, C., Litthauer, D., Van Niekerk, H., Van Eeden, J., Lollar, B.S., Onstott, T.C. and Van Heerden, E., (2015). Eukaryotic opportunists dominate the deep-subsurface biosphere in South Africa. Nature Communications, 6. Impact factor 11.470

     

  • TE Motaung, J Albertyn, CH Pohl (2015). Candida albicans mutant construction and characterization of selected virulence determinants. Journal of Microbiological methods. 115, 153-165. Impact factor 1.857

     

  • Madu, U.L., Ogundeji, A.O., Mochochoko, B.M., Pohl, C.H., Albertyn, J., Swart, C.W., Allwood, J.W., Southam, A.D., Dunn, W.B., May, R.C. and Sebolai, O.M. (2015). Cryptococcal 3-hydroxy fatty acids protect cells against amoebal phagocytosis. Frontiers in Microbiology, 6 (DEC). Impact factor: 4.165

     

  • Ells R, Kilian W, Hugo A, Albertyn J, Kock JLF & Pohl CH. (2014) Virulence of South African Candida albicans strains isolated from different clinical samples. Medical Mycology 52: 246-253. Impact factor 1.857

     

  • Theron CW, Labuschagné M, Gudiminchi R, Albertyn J, Smit MS. (2014). A broad-range yeast expression system reveals Arxula adeninivorans expressing a fungal self-sufficient cytochrome P450 monooxygenase as an excellent whole-cell biocatalyst. FEMS Yeast Res. 2014 Feb 13. Impact factor 2.818

     

  • Ells R, Kemp G, Albertyn J, Kock JLF, and Pohl CH. (2013). Phenothiazine is a potent inhibitor of prostaglandin E2 production by Candida albicans biofilms. FEMS Yeast Research. 13: 849-855. Impact factor 2.436

     

  • Charimba G, Jooste P, Albertyn J and Hugo C. (2013). Chryseobacterium carnipullorum sp. nov., isolated from raw chicken. Journal of Systematic and Evolutionary Microbiology. International Journal of Systematic and Evolutionary Microbiology. 63:3243-3249. Impact factor 2.798

 

Motaung T, Albertyn J, Kock JLF, Lee C-F, Suh S-O, Blackwell M, Pohl CH. (2013). Trichosporon vanderwaltii sp. nov., an asexual basidiomycetous yeast isolated from soil and beetles. Antonie van Leeuwenhoek 103:313–319 (impact factor: 2.137).


Research


Area(s) of Interest

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Courses Presented

 

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FACULTY CONTACT

Elfrieda Lötter: Marketing Manager
T: +27 51 401 2531
E:lottere@ufs.ac.za


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