Dr Frans O'Neill
Position
Senior Lecturer
Department
Microbial Biochemical and Food Biotechnology
Address
BTG
Microbial Biochemical and Food Biotechnology
IB 61
Telephone
7553
Office
Microbial, Biochemical And Food Biotechnology 5
Information

Short CV

Frans Hendrik O`Neill

Born: 08 February 1971, Douglas, South Africa.

Academic qualifications:

DEGREE       YEAR             INSTITUTION                                    FIELD OF STUDY

Ph.D.              1999-2002     Imperial College, London               Lipidology

M.Sc.              1994-1997     University of the Free State           Microbiology

B.Sc. Hons.   1993               University of the Free State           Microbiology

B.Sc.               1990-1992     University of the Free State           Microbiology & Biochemistry

 

Employment:

Jan 2012 – present  Senior Lecturer, Department of Microbial, Biochemical and Food
                                    Biotechnology, University of the Free State

2008 – 2011              Postdoctoral fellow, School of Biochemistry, North-West University

2003 – 2007              Postdoctoral fellow, Lipid Laboratory, University of Cape Town

  

Research:

- Sterol metabolism, in particular that of plant sterols in different species.

- Reproductive hormones for animal use.

- Cellular detoxification, in particular CYP3A4 in phase I and GLYAT in phase II of detoxification.

 


Publications


Publications (Short List)

  1.  Sabiu S, Ajani EO and O’Neill FH. Membrane stabilization and andro-spermatogenic potential of standardized fraction of Cyperus esculentus L. Indian J Tradit Know. Vol 17, p. 78-84, 2018.
  2. Sabiu S, O’Neill FH and Ashafa AOT. Toxicopathological evaluation of a 28-day repeated dose adminitration of Zea mays L. (Poaceae), Stigma maydis aqueous extract on key metabolic markers of Wistar rats. Trans R Soc S Afr. Vol 72, p. 225-233, 2017.
  3. Sabiu S, O’Neill FH and Ashafa AOT. Zea mays, Stigma maydis prevents and extenuates acetaminophen-perturbed oxidative onslaughts in rat hepatocytes. Pharm Biol. Vol 54, p. 2664-2673, 2016.
  4. Sabiu S, O’Neill FH and Ashafa AOT. The purview of phytotherapy in the management of kidney disorders: a systematic review on Nigeria and South Africa. Afr J Tradit Complement Altern Med. Vol. 13, p. 38-47, 2016.
  5. Sabiu S, O’Neill FH and Ashafa AOT. Kinetics of a-amylase and a-glucosidase inhibitory potential of Zea mays Linnaeus (Poaceae), Stigma maydis aqueous extract: An in vitro assessment. J Ethnopharmacol. Vol. 183, p. 1-8, 2016.
  6. Blackhurst DM, Pietersen R-D, O’Neill FH and Marais AD. Marinating beef with South African red wine may protect against lipid peroxidation during cooking. Afr J Food Sci. Vol. 5, p. 650-656, 2011.
  7. O`Neill FH, Sanders TA and Thompson GR. Comparison of efficacy of plant stanol ester and sterol ester: short-term and longer-term studies.Am J Cardiol. Vol. 96, p. 29D-36D, 2005.
  8. Blom DJ, O`Neill FH and Marais AD. Screening for dysbetalipoproteinemia by plasma cholesterol and apolipoprotein B concentrations. Clin Chem. Vol. 51, p.904-907, 2005.
  9. O`Neill FH, Brynes A, Mandeno R, Rendell N, Taylor G, Seed M and Thompson GR. Comparison of the effects of dietary plant sterol and stanol esters on lipid metabolism. Nutr Metab Cardiovasc Dis. Vol. 14, p. 133-142, 2004
  10. Watts GF, Chan DC, Barrett PH, O`Neill FH and Thompson GR. Effect of a statin on hepatic apolipoprotein B-100 secretion and plasma campesterol levels in the metabolic syndrome. Int J Obes Relat Metab Disord. Vol. 27, p. 862-865, 2003.
  11. Chan DC, Watts GF, Barrett PH, O`Neill FH and Thompson GR. Plasma markers of cholesterol homeostasis and apolipoprotein B-100 kinetics in the metabolic syndrome. Obes Res. Vol. 11, p. 591-596, 2003.
  12. Chan DC, Watts GF, Barrett PH, O`Neill FH, Redgrave TG and Thompson GR. Relationships between cholesterol homoeostasis and triacylglycerol-rich lipoprotein remnant metabolism in the metabolic syndrome. Clin Sci (Lond). Vol. 104, p. 383-388, 2003.
  13. Naoumova RP, Patel DD, O’Neill FH, Thompson GR and Knight BL. Treatment with atorvastatin alters the ratio of interleukin-12/interleukin-10 gene expression. Eur. J. Clin. Invest. Vol. 33, p. 88-91, 2003.
  14. Thompson GR, O`Neill F. and Seed M. Why some patients respond poorly to statins and how this might be remedied. Eur Heart J. Vol. 23, p.200-206, 2002.
  15. O’Neill FH, Patel DD, Knight BL, Neuwirth CKY, Bourbon M, Taylor GW, Thompson GR and Naoumova RP. Determinants of variable response to statin treatment in patients with familial hypercholesterolaemia. Arterioscler Thromb Vasc Biol. Vol. 21, p. 832-837, 2001.
  16. Naoumova RP, O’Neill FH, Dunn S, Neuwirth CKY, Taylor GW, Axelson M and Thompson GR. Effect of inhibiting HMG-CoA reductase on 7a-hydroxy-4-cholesten-3-one, a marker of bile acid synthesis: contrasting findings in patients with and without prior up-regulation of the latter pathway. Eur J Clin Invest. Vol. 29, p.404-412, 1999.
  17. Christov LP, Myburgh J, O’Neill FH, Van Tonder A. and Prior BA.Modification of the carbohydrate composition of sulfite pulp by purified and characterized beta-xylanase and beta-xylosidase of Aureobasidium pullulans. Biotechnology Progress. Vol. 15, p.196-200, 1999.
  18. O`Neill FH, Christov LP, Botes PJ and Prior BA. A rapid and simple assay for feruloyl and r-coumaroyl esterases.World Journal of Microbiology and Biotechnology, Vol. 12, p.239-242, 1996.

Research


Area(s) of Interest


Courses Presented


Community Service


Service Learning


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FACULTY CONTACT

Elfrieda Lötter: Marketing Manager
T: +27 51 401 2531
E:lottere@ufs.ac.za


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