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05 April 2018 Photo Xolisa Mnukwa
Global genealogy explored at UFS guest lecture
Karen Ehlers, lecturer in Department of Genetics; Prof Eugenia D’Amato, guest lecturer and Associate Professor: Department of Biotechnology at the UWC, and Prof Paul Grobler Head of Department: Genetics at the UFS.

Prof Eugenia D’Amato held a lecture at the University of the Free State (UFS) Department of Genetics about the research activities she has conducted in her unit at the University of the Western Cape (UWC), in the Forensic DNA lab of the Faculty of Natural Sciences.
 
The lecture focused on research topics she has piloted, including the use of forensic markers in South Africa. Prof D’Amato also spoke on food forensics, the identification of anti-apartheid activists, understanding human genetic variation, and the implementation of novel/refined methods, with a strong emphasis on the forensic use of Y chromosome-based information.

She concluded her PhD studies at the University of Buenos Aires in Argentina, at the forensic lab. Currently, Prof D’Amato participates in numerous genotyping international forensic collaborations.

 “A survey of existing genetic diversity,
the distribution of diversity, the forensic
parameters and applications are a few of
the subject matters which are important
components of the GlobalFiler project.”
Prof Eugenia D’Amato

She also belongs to the working committee of the “Innocence Project South Africa”.

Her training and subsequent experience in population genetics facilitated the design of a Y chromosome “kit”, as well as the analysis and successful identification of various individuals from highly degraded DNA. Her lecture revealed interesting statistics about how poorly represented African diversity is in the existing world population databases. She explained that mechanisms that drive differentiation include random “genetic drift” and historic demographic processes.
 
Prof D’Amato indicated that her “Database Projection” project for 2018/2019 aims at profiling the population groups of South Africa, Lesotho, and Zimbabwe. She further explained that a powerful tool for forensic application has been developed, and that there is potential for other applications including haplogroup prediction and the study of demographic history, that will aid her projects in the future.

News Archive

New research informs improved treatment of brain inflammation
2017-10-13

Description: Sebolai and Ogundeji Tags: Microbiologist, Dr Adepemi Ogundeji,  

Dr Adepemi Ogundeji, researcher in the Department of Microbial,
Biochemical and Food Biotechnology at the
University of the Free State,
and Dr Olihile Sebolai,
her study leader from the same department.
Photo: Charl Devenish



Microbiologist Dr Adepemi Ogundeji has uncovered a new use for an old medicine that can potentially save lives and money. Under the guidance of her study leader, Dr Olihile Sebolai, Dr Ogundeji set out to fight a fungal disease caused by Cryptococcus neoformans. Drs Ogundeji and Sebolai are from the University of the Free State Department of Microbial, Biochemical and Food Biotechnology. 

Dr Ogundeji is passionate about education. “My aim will always be to transfer knowledge and skills in the microbiology field,” she said. “Dr Ogundeji’s study is celebrated in that it found a new purpose for existing medicines. An advantage of repositioning old medicines is by-passing clinical trials, which sometimes take 20 years, and the safety of such medicines is already known,” Dr Sebolai, explained.

Cryptococcus infections are difficult to control and often lead to brain inflammation. In layman’s terms: “Your brain is on fire”. People with HIV/Aids are especially vulnerable, surviving only about three months without treatment. Such patients may present with a Cryptococcus-emergent psychosis, and some with an out-of-control inflammatory condition when initiated on ARVs. 

Dr Ogundeji found that the clinically recommended dosage of aspirin (anti-inflammatory medicine), and quetiapine (anti-psychotic medicine) is sufficient to control the infection. Her exceptional work was readily published in some of the foremost journals in her field, namely, Antimicrobial Agents and Chemotherapy and Frontiers in Microbiology

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