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05 April 2018 Photo Xolisa Mnukwa
Global genealogy explored at UFS guest lecture
Karen Ehlers, lecturer in Department of Genetics; Prof Eugenia D’Amato, guest lecturer and Associate Professor: Department of Biotechnology at the UWC, and Prof Paul Grobler Head of Department: Genetics at the UFS.

Prof Eugenia D’Amato held a lecture at the University of the Free State (UFS) Department of Genetics about the research activities she has conducted in her unit at the University of the Western Cape (UWC), in the Forensic DNA lab of the Faculty of Natural Sciences.
 
The lecture focused on research topics she has piloted, including the use of forensic markers in South Africa. Prof D’Amato also spoke on food forensics, the identification of anti-apartheid activists, understanding human genetic variation, and the implementation of novel/refined methods, with a strong emphasis on the forensic use of Y chromosome-based information.

She concluded her PhD studies at the University of Buenos Aires in Argentina, at the forensic lab. Currently, Prof D’Amato participates in numerous genotyping international forensic collaborations.

 “A survey of existing genetic diversity,
the distribution of diversity, the forensic
parameters and applications are a few of
the subject matters which are important
components of the GlobalFiler project.”
Prof Eugenia D’Amato

She also belongs to the working committee of the “Innocence Project South Africa”.

Her training and subsequent experience in population genetics facilitated the design of a Y chromosome “kit”, as well as the analysis and successful identification of various individuals from highly degraded DNA. Her lecture revealed interesting statistics about how poorly represented African diversity is in the existing world population databases. She explained that mechanisms that drive differentiation include random “genetic drift” and historic demographic processes.
 
Prof D’Amato indicated that her “Database Projection” project for 2018/2019 aims at profiling the population groups of South Africa, Lesotho, and Zimbabwe. She further explained that a powerful tool for forensic application has been developed, and that there is potential for other applications including haplogroup prediction and the study of demographic history, that will aid her projects in the future.

News Archive

Oxford professor unlocks secrets of DNA
2017-03-31

Description: Oxford professor unlocks secrets of DNA Tags: Oxford professor unlocks secrets of DNA

From left are: Dr Cristian Capelli, Associate Professor
of Human Evolution at Oxford University;
Dr Karen Ehlers, Senior Lecturer and Prof Paul Grobler,
both from the Department of Genetics at the UFS.
Photo: Siobhan Canavan

Many people are interested to know more about their history and origins, and with the help of genetics, it is possible to provide more information about one’s roots.

During a lecture at the Department of Genetics at the University of the Free State (UFS), Dr Cristian Capelli, Associate Professor of Human Evolution at Oxford University in the UK, addressed staff members and students on the history of our species.

Reconstructing the history of human population
With his research, titled: People on the move: population structure and gene-flow in Southern Africa, Dr Capelli looks at reconstructing the history of human populations, focusing mainly on how the different human populations are related, as well as how they exchange genes.

He said this research could be of great significance to the medical field too. “Knowing what the genetic make-up of individuals is, can give us some information about their susceptibility to diseases, or how they would react to a given medicine. Therefore, this knowledge can be used to inform health-related policies.”

Combining individual histories of multiple people
To understand this research more clearly, Dr Capelli explained it in terms of DNA and how every individual receives half of their DNA from their mother and half from their father just as their parents had received theirs from their parents. And so it goes from generation after generation. Each individual stores a part of their ancestors’ DNA which makes up the individual genetic history of each person.

“If we combine these individual histories by looking at the DNA of multiple people, we can identify the occurrences that are shared across individuals and therefore reconstruct the history of a population, and in the same way on a larger scale, the history of our own species, homo sapiens.

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