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24 August 2018 Photo Igno van Niekerk
Chemistry changing the world to create a better future
These practical applications of Chemistry are part of the relevant and practically applicable research Prof André Roodt (far left) and his research group are involved in. With him are Dr Ebrahiem Botha, Post-doctoral fellow; Pheelo Nkoe, PhD student; Shaun Redgard, MSc student; and Dr Orbett Alexander, Post-doctoral fellow
Some people have a gift for explaining the most complex concepts in a way anyone could understand. Combine this gift with passion, energy, and enthusiasm, and you are close to describing a meeting with Prof André Roodt. 

Prof Roodt not only teaches Chemistry, he lives it. He has published more than 320 papers, lectured internationally more than 100 times, and has guided 35 PhD and 48 MSc students to complete their degrees. These figures are likely to conjure up visions of a dusty academic working on pie-in-the-sky theories. 

Adding value

Within minutes you are made aware of the fact that Chemistry is not only a subject confined to classrooms and labs. It is a means of changing the world through research to create a better future. In academic terms, Prof Roodt and his team are involved in ‘Homegeneous Catalysis’, ‘Radiopharmacy: Theranostics’, ‘Metal Benefication’, and ‘Conversion of carbon dioxide and water’. And just when you start to remember how terrifying high-school Chemistry was, Prof Roodt explains the practical nature of what they are doing.

Few of us are aware of the exact processes that produce fuel for our cars, although we probably know that these processes have side effects which are usually detrimental to the environment; but what if the by-products of these processes can be turned into speciality chemicals which could add value in different ways?

Ever wondered how medication know where to go in your body? Well – just imagine highly specialised (clever) pharmaceutical agents giving off their own ‘light’, knowing exactly where to go, showing you where they are going, and knowing what to do in order to provide information and interact with specific cells in your body to assist in healing cells and fighting disease. Exciting.

Passionate people

But, as they say in the ads, that is not all; imagine better ways to generate power, using the natural processes in plants to increase natural oxygen where needed, and to be able to change oxygen levels in the environment.

These practical applications of Chemistry are part of the relevant and practically applicable research Prof Roodt and his research group are involved in.

When you leave Prof Roodt’s office, you realise that this is what the UFS is all about: Global impact. World-class research. Passionate people. And seizing the opportunity to create the future.

News Archive

Mathematical methods used to detect and classify breast cancer masses
2016-08-10

Description: Breast lesions Tags: Breast lesions

Examples of Acho’s breast mass
segmentation identification

Breast cancer is the leading cause of female mortality in developing countries. According to the World Health Organization (WHO), the low survival rates in developing countries are mainly due to the lack of early detection and adequate diagnosis programs.

Seeing the picture more clearly

Susan Acho from the University of the Free State’s Department of Medical Physics, breast cancer research focuses on using mathematical methods to delineate and classify breast masses. Advancements in medical research have led to remarkable progress in breast cancer detection, however, according to Acho, the methods of diagnosis currently available commercially, lack a detailed finesse in accurately identifying the boundaries of breast mass lesions.

Inspiration drawn from pioneer

Drawing inspiration from the Mammography Computer Aided Diagnosis Development and Implementation (CAADI) project, which was the brainchild Prof William Rae, Head of the department of Medical Physics, Acho’s MMedSc thesis titled ‘Segmentation and Quantitative Characterisation of Breast Masses Imaged using Digital Mammography’ investigates classical segmentation algorithms, texture features and classification of breast masses in mammography. It is a rare research topic in South Africa.

 Characterisation of breast masses, involves delineating and analysing the breast mass region on a mammogram in order to determine its shape, margin and texture composition. Computer-aided diagnosis (CAD) program detects the outline of the mass lesion, and uses this information together with its texture features to determine the clinical traits of the mass. CAD programs mark suspicious areas for second look or areas on a mammogram that the radiologist might have overlooked. It can act as an independent double reader of a mammogram in institutions where there is a shortage of trained mammogram readers. 

Light at the end of the tunnel

Breast cancer is one of the most common malignancies among females in South Africa. “The challenge is being able to apply these mathematical methods in the medical field to help find solutions to specific medical problems, and that’s what I hope my research will do,” she says.

By using mathematics, physics and digital imaging to understand breast masses on mammograms, her research bridges the gap between these fields to provide algorithms which are applicable in medical image interpretation.

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