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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.

South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

Two from UFS heading for Rio
2016-07-18

Description: Rynhardt_Rio Tags: Rynhardt_Rio

The 800 m athlete from the University of the
Free State, Rynhardt van Rensburg, will soon
take part in his first Olympic Games in
Rio de Janeiro, Brazil.
Photo: Varsity Sports / Wessel Oosthuizen

It is the cherry on top for any sportsman or sportswoman. This is what DB Prinsloo, Director of KovsieSport, has to say about two athletes from the University of the Free State (UFS) being included in the South African team for the Olympic Games.

He says the officials and coaches at KovsieSport are extremely proud of Rynhardt van Rensburg (800 m) and Wayde van Niekerk (400 m). Although they qualified earlier, their names were read out on 14 July 2016 as part of the team of 137 athletes that will participate in Rio de Janeiro, Brazil, from 5 to 21 August.

In the footsteps of other UFS stars

They follow in the footsteps of former Kovsies like Leslé-Ann George (women’s hockey), Kate Roberts (triathlon), Johan Cronjé (1 500 m), and Frantz Kruger (discus), who represented South Africa at previous Olympics. Apart from these two, four former Kovsies were also included in the team for Rio. They are the Sevens Springbok Philip Snyman, Sevens coach Neil Powell, Chris Dednam as badminton coach and Roberts as team manager of the triathletes. Dednam also competed as a player at the Olympics. Ans Botha, the UFS sprint coach, will also accompany Van Niekerk.

“It is a highlight for any sportsman or sportswoman to be part of the Olympic Games. It is, for example, the same as it is for others to participate in a World Cup,” says Prinsloo.

Description: Wayde2_Rio Tags: Wayde2_Rio

Wayde van Niekerk

Van Niekerk shows mettle on birthday

Prinsloo is very happy for Van Rensburg, since the 24-year-old athlete has been injured for a long time and had to regain his form. On 24 June 2016, he won a bronze medal at the African Championships in Durban in a time of 1:46.15.

Prinsloo feels that Van Niekerk and Caster Semenya (800 m) are great contenders for medals in Rio. Van Niekerk, who celebrated his 24th birthday on 15 July 2016, continued his good preparation for the Olympics by trouncing his rivals on his birthday at a Diamond League event in Monaco in a time of in 44.12.

 

“It is a highlight for any sportsman or
sportswoman to be part of the Olympic Games.”










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