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10 December 2018 | Story Leonie Bolleurs | Photo Leonie Bolleurs
One step closer to treat HIV/Aids
Nthabiseng Mokoena is working on an article based on her research about drug development in infection models, which will be published under the Research Chair in Pathogenic Yeasts.

South Africa has the biggest and most high-profile HIV epidemic in the world, with an estimated seven million people living with HIV in 2015. In the same year, there were 380 000 new infections while 180 000 South Africans died from AIDS-related illnesses. 

Invasive fungal infection, common in certain groups of patients with immune deficits, is a serious driver of global mortality in the context of the global HIV pandemic. 

“Despite a major scientific effort to find new cures and vaccines for HIV, hundreds of thousands of HIV-infected individuals continue to die on a yearly basis from secondary fungal infection. Intensive research needs to be done to help reduce the unacceptably high mortality rate due to the infection in South Africa,” said Nthabiseng Mokoena.

Mokoena is a master’s student of Prof Carlien Pohl-Albertyn, who is heading the Research Chair in Pathogenic Yeasts in the Department of Microbial, Biochemical and Food Biotechnology at the University of the Free State (UFS). 

She received her master’s degree at the December graduations of the UFS. Her thesis is titled: Caenorhabditis elegans as a model for Candida albicans-Pseudomonas aeruginosa co-infection and infection induced prostaglandin production.

Research Chair in Pathogenic Yeasts

Earlier this year, the National Research Foundation approved the Research Chair in Pathogenic Yeasts. One of the projects of the group of scientists in this chair include a study of the interaction between the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa in different hosts, using a variety of infection models.

In her research, Mokoena studied the response of infectious pathogens such as yeasts and bacteria, using a nematode (little roundworm) as an infection model to mimic the host environment. Nematodes have a number of traits similar to humans. It is thus a good alternative for humans as infection models, as it is unethical to use the latter.

Nematodes have a number of advantages, including its low cost and fast reproduction and growth. 

Mokoena monitored the survival of the nematodes to see how infectious the pathogens are, especially in combination with each other. 

Role of infection model for drug development

When these two pathogens were studied in a lab (in vitro), it was found that they can inhibit each other, but after studying them in the infection model (in vivo), Mokoena showed that these pathogens are more destructive together. 

This finding has a huge impact for the pharmaceutical industry, as it can provide information on how drugs need to be designed in order to fight infectious diseases where multiple organisms cause co-infections.

Many pathogens are resistant to drugs. Through this model, drugs can be tested in a space similar to the human body. Seeing how pathogens react to drugs within a space similar to the human body, can contribute to drug development. 

Not only are drugs developed more effectively through this model, it is also less expensive. 

It is the first time that the combination of the yeast, Candida albicans and the bacterium, Pseudomonas aeruginosa, is being experimented on in this model. 

News Archive

Knific Duo from US lecture and perform at OSM
2017-05-12

Description: ' 000 Knific Duo Tags: Knific Duo

Profs Tom Knific and Renata Artman Knific from the Western
Michigan University School of Music are visiting the Odeion
School of Music at the University of the Free State.
Photo: Supplied

The renowned Knific Duo will not only perform at the University of the Free State (UFS) soon, but will also share their expertise at the Odeion School of Music (OSM). The duo, consisting of Profs Tom Knific and Renata Artman Knific, from the prestigious Western Michigan University School of Music, are presenting a masterclass series hosted by the OSM Concert Agency. The series takes place from 10-14 May 2017 and the concert on 16 May 2017.

Concert features local pianists

The first half of the concert on 16 May 2017 will present a programme leaning towards the classical genre. Apart from three works composed by Prof Knific, it will also include two movements from the Violin Sonata by the Hungarian composer Miklós Rózsa. 
In the second half Prof Knific will collaborate with two local pianists, the legendary jazz pianist, composer and music educator, Noel Stockton, and the talented Andile Qongqo, and for a carefully curated jazz programme mainly from the oeuvre of Prof Knific. Random Dreams, a work composed by Stockton will also be included.

Well-known around the world

Prof Knific (double bass) is a Professor at the Department of Jazz at the Western Michigan University School of Music. He has been principal bassist of orchestras from the US to Europe and performed as a soloist and in chamber music festivals around the world. He also is a former president of the International Society of Bassists.

Prof Artman Knific (violin) is a professor of violin at the same institution. Her international career began in London at 21 when she joined the English Chamber Orchestra. Tours of Europe, North and South America and Asia followed where she collaborated with artists such as Herman Bauman and Isaac Stern. She has worked with conductors such as Daniel Barenboim and Christoph Eschenbach, and recorded records for EMI, Decca, and CBS labels.
 
Date: 16 May 2017
Time: 19:30
Place: Odeion (Bloemfontein Campus)

Musicians interested in masterclasses can contact Ninette Pretorius at  pretoriusn@ufs.ac.za

 

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