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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

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Visiting Professor, Piet Bracke, Speaks on Public Mental Health
2015-02-20

Piet Bracke

Professor in the Department of Sociology at the Ghent University in Belgium, Piet Bracke, recently visited the UFS to speak about his research on the Public mental health and comparative health research: between social theory and psychiatric epidemiology.

At the public lecture on Monday 16 February, Bracke stated that part of the sociological attention to mental health and well-being was rooted in the 19th century's romanticists' discontent with self and society. The classical and contemporary social theorists' views on the disconnection between culture and the ‘real’ self resembles the more recent evolutionary psychological assumptions about the maladaptation of  psychobiological mechanisms to contemporary societal arrangements.

In contrast to these perspectives, contemporary psychiatric epidemiological research has a strongly underdeveloped conception about the nexus between society and population mental health. Both perspectives, the social-theory-and-societal-discontent approach and the biomedical psychiatric epidemiological approach, have drawbacks. Starting from the pitfalls of the aforementioned perspectives, they have been exploring the challenges posed by the development of a macro-sociology of population mental health.

Recently, this research domain has received renewed attention of scholars inside as well as outside sociology. The rise of multi-country, multilevel datasets containing health-related information, as well as the growing attention on the fundamental social causes of health and illness, and the focus on population as opposed to individual health, has contributed to the revival of comparative public mental health research. Based on findings from their recent research, they have illustrated how taking the context into account is vital when exploring the social roots of mental health and illness. In addition, they have demonstrated how they can liberate a few so-called ‘control variables’ in risk factor epidemiology – e.g. gender, education, and age – from their suppressed status by linking them to core concepts of sociology. With their research, they hope to further the development of a macro-sociology of public mental health.

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