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24 December 2018 | Story Leonie Bolleurs | Photo Anja Aucamp
Research possibilities of zebrafish exposed
Leading global genetics laboratories are replacing research on human and animal populations with zebrafish, says Prof Paul Grobler, Head of the UFS Department of Genetics.

The UFS Department of Genetics is on par with current research trends in terms of their zebrafish project. About a year has passed since they seriously started focusing on the potential of this tiny four-centimetre-long fish, and the possibilities are hugely exciting.

Looks are deceiving

Leading global genetics laboratories are replacing research on human and animal populations with zebrafish due to several fascinating reasons, of which the most profound is probably that the zebrafish share large portions of its genome with mammals. For genetics researchers this may make a lot of sense, but most people battle to see any resemblance between a six-foot-tall rugby player or 600 kg buffalo and a small, nearly transparent fish. It is in the detail, the researchers say.

Fast, effective, and visible

“The complete genome sequence of the zebrafish is known, and as much as 84% of genes known to be associated with human disease have zebrafish counterparts,” explains Head of Department, Prof Paul Grobler. Another advantage is the fast breeding rate and short generation time, and the fact that some research is ethically more justifiable when done on fish larvae rather than on adult mammals. The fact that zebrafish embryos are virtually transparent, also allow researchers to examine the development of internal structures without effort. Every blood vessel in a living zebrafish embryo is visible under a low-power microscope.

Multidisciplinary

Zebrafish provide research potential for many different study fields besides that of Prof Grobler and his team, Sue Rica Schneider and Dr Willem Coetzer. In the near future, they aim to have undergraduate students use zebrafish as a research model to develop a real sense of research and laboratory work. The Department of Chemistry are also initiating research on zebrafish housed in the Department of Genetics.

News Archive

Charity indeed begins at home
2016-02-19

Description: KL News 2016 02 19 Rag Queen Tags: KL News 2016 02 19 Rag Queen
The winning duo: Stefan Lotter and Marzel van Zyl after being crowned Mr RAG and RAG Queen at the Brutal Fruit Coronation Ball. Photo: Sarel Greyling

Stefan Lotter and Marzel van Zyl were crowned Mr RAG and RAG Queen at the prestigious Brutal Fruit RAG Coronation Ball on 12 February 2016. For the last 10 months, these University of the Free State (UFS) students have been collecting funds for community projects in the Free State.

Capitalise on existing platforms

Although they are patrons of charitable organisations external to the university, Stefan and Marzel revised their strategy to prioritise the UFS. “Some students on campus struggle, and, because charity begins at home, we will try to help the No Student Hungry and Right to Learn campaigns,” said Stefan.

However, he will continue to support the Northern Free State Caregivers, a 24-hour nursing service for terminally ill patients, for which he collected R15 000. For her part, Marzel was able to collect more than R20 000 for the Free State Residential Care Centre, which houses mentally challenged adults, and also hosts a skills development programme. The Centre’s baking workshop had to discontinue due to a lack of funding, but Marzel hopes that her contributions will bring about its revival and sustenance.

Bringing home the money

The winning duo are expected to represent our university at Mr & Miss SA Campus South Africa 2016.  According to Stefan, they plan “to push the RAG agenda there and bring money back home,” at this charity-based pageant.

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