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14 February 2018 Photo Bonolo Nkoane
First Sesotho soundtrack for fulldome film launched at Naval Hill Planetarium
Tshireletso Nkoane, best known for her television roles in the drama series, Tshisa, the comedy series, Moferefere Lenyalong, as well as the miniseries, Naledi.

In December, the Naval Hill Planetarium used the voice of a well-known South African actress for yet another trailblazer: the first Sesotho soundtrack for a full-dome film.

“It is important for our children to become interested in science and astronomy through exposure to good language use in their mother tongue from an early age, so that we can still make a sound contribution to these fields in the future,” said Prof Matie Hoffman from the Department of Physics at the University of the Free State.

Space Shapes, a child-friendly fulldome film by the Ott Planetarium at the Weber State University in Utah in the US, was translated into Sesotho as Dibopeho tsa Sepakapakeng by Khantlapane Selina Ketla and Dr Andries Hoffman, following last year’s release of the short film by the Naval Hill Planetarium as Ruimtevorms in Afrikaans. The film, created by participants of the 2010 Blender Production Workshop in Utah, takes young audiences on a journey to explore the different shapes found in space.

The voice artist, Tshireletso Nkoane, a star in her own right, is best-known for her television roles in the drama series, Tshisa, the comedy series, Moferefere Lenyalong, as well as the miniseries, Naledi. She has several theatre and radio credits to her name, and also boasts a diploma in Electrical Engineering.

The premiere of this Sesotho trailblazer, as well as the CosmoQuest and Ward Beecher Planetarium’s English fulldome film, Cosmic Castaways, will take place at the Naval Hill Planetarium on Saturday 17 February 2018 at 17:30. Cosmic Castaways is an exciting work that reaches out to places where there are no constellations; where there are still isolated stars to be found in the voids between the galaxies.

Tickets for this double premiere, as well as for the weekly Saturday 17:30 shows, are available from Computicket – just search under ‘planetarium’ on the Computicket website or visit Checkers.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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