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12 February 2018 Photo Supplied
UFS researcher programme aids pupils with ADHD and dyslexia
Dr Carol Goldfus

Many years ago, as a secondary school teacher, Dr Carol Goldfus from the University of the Free State’s Unit for Language Facilitation and Empowerment, realised that reading comprehension ought to be the focal point of teaching. She came to the conclusion that many adolescents were unable to gain fluency in English as a foreign language despite many years of study and that there were those who struggled with the foreign language. With her postgraduate specialisation in neuroscience and the merging of neuroscience and education, she developed a reading comprehension intervention programme.

Reading remains important

Contrary to what we believe, the world is not more visual – but rather more technical, Dr Goldfus explains, and reading with understanding remains of utmost importance in the twenty first century. “Literacy does not only mean reading, but also thinking fast,” she says, “with the ability to sift through the mass of available information. Without reading proficiency, people cannot succeed in a world with so much information. In fact, the ability to identify what is important, and what not, is more crucial than before.”

““It is our duty to give
pupils worldwide the ability
to cope with a sophisticated,
alienated, and technological world.”
—Dr Carol Goldfus
ULFE

One brain, many languages

Reading comprehension is the epicentre of Dr Goldfus’s approach to learning, and her intervention programme may benefit any pupil who is unable to cope with the demands of the academic setting, and can be applied to any language. These pupils include children from seventh to twelth grade (12 to 18 years of age) who read without comprehension, have dyslexia, dyscalculia (problems with maths), and ADHD (Attention Deficit with or without Hyperactivity), or have dropped out of an education setting. “My intervention programme is in English as a Foreign Langue (EFL) but is not static, since it is based on principles from neuroscience and linguistics that are placed in the world of education. Although it is for EFL, it has a backwash effect on mother-tongue reading competence as well. Each programme comprises certain core principles, like developing self-esteem, monitoring comprehension and learning, and developing long-term memory storage. Without remembering, there is no learning.”

No one wants to fail

Dr Goldfus feels that it is our duty to give pupils worldwide the ability to cope with a sophisticated, alienated, and technological world. “My goal is to turn failure into excellence through an understanding of how the brain works. That is what the programme and my research can offer: creating a brain that can support learning where each pupil can fulfil his or her potential.”

Her work is so noteworthy, that Dr Goldfus received a Blue Skies Grand from the National Research Foundation of South Africa for her research: Graphomotor synchronisation to musical stimulation as a diagnostic tool for dyslexia. This proposed interdisciplinary research addresses dyslexia, a language-related disability, through the language of music and encompasses three disciplines: music cognition, physics and education.

News Archive

Nuclear Medicine on the forefront of cancer research
2017-07-10

Description: Nuclear Medicine on the forefront of cancer research Tags: Nuclear Medicine, cancer research, Dr Je’nine Horn-Lodewyk’s, tumour detection method, cancer, Department of Nuclear Medicine 

Dr Je’nine Horn-Lodewyk’s tumour detection method
could be the cost-effective breakthrough needed to decrease
the mortality rate in breast cancer patients.
Photo: Anja Aucamp

The field of Nuclear Medicine in South Africa and the rest of the world are expanding rapidly due to the development of hybrid cameras and new radiopharmaceuticals. These developments have a huge impact on the diagnosis and therapy of cancer.

The most advanced of these cameras, Positron emission tomography combined with normal CTs (PETCT), are not yet widely available in South Africa due to the cost of the cameras and the radiopharmaceuticals. A more cost-effective alternative can be of great benefit. To achieve this, the focus should be on developing new radiopharmaceuticals that can be used with the current cost-effective gamma cameras, according to University of the Free State researcher, Dr Je’nine Horn-Lodewyk from the Department of Nuclear Medicine.

Fluorodeoxyglucose (18F-FDG), a radiolabelled glucose analogue, is currently the radiopharmaceutical most commonly used in PET/CT imaging for mainly oncology indications. Although it is considered the gold standard for imaging in several malignancies, it does have certain disadvantages. An 18F-FDG PET/CT diagnostic imaging study can cost between R25 000 and R35 000 for a single patient in the private sector. The 18F-FDG is also more radioactive, which requires much stricter handling and shielding to avoid high radiation dosages to staff and patients.

Successful research potential innovative solution
In the search for the ideal radiopharmaceutical for tumour detection, the South African National Nuclear Energy Corporation (Necsa) developed a local synthesis process for ethylenedicysteine-deoxyglucose (EC-DG). EC-DG is also a glucose analogue similar to FDG. They succeeded in labelling the compound with Technetium-99-metastable-pertechnetate (99mTcO4-), the most common nuclear medicine isotope used for approximately 95% of nuclear medicine procedures, creating 99mTc-EC-DG.

In partnership with Dr Horn-Lodewyk, this compound was successfully used in various animal models and clinical scenarios, resulting in approval by the Medicine Control Council to use it in a human study. Research is also planned in order to investigate diagnostic accuracy in other cancers like lymphoma.  The end result of this research can produce a radiopharmaceutical that is cost effective, does not require the use of costly specialised equipment, has no significant side-effects, no special patient preparation, renders late imaging possible, and has decreased radiation risks.

Dr Horn-Lodewyk is grateful for the support of her mentor, Prof Anton Otto, as well as Dr Gert Engelbrecht, Head of the Department of Nuclear Medicine, Prof Jan Rijn Zeevaart from North-West University’s Preclinical Drug Development Platform and Necsa, and Judith Wagener from Necsa. This innovative research would also not have been possible without the financial assistance of Dr Glen Taylor and Eleanor van der Westhuizen in the Directorate of Research Development.

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