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UFS researcher programme aids pupils with ADHD and dyslexia
Dr Carol Goldfus

Many years ago, as a secondary school teacher, Dr Carol Goldfus from the University of the Free State’s Unit for Language Facilitation and Empowerment, realised that reading comprehension ought to be the focal point of teaching. She came to the conclusion that many adolescents were unable to gain fluency in English as a foreign language despite many years of study and that there were those who struggled with the foreign language. With her postgraduate specialisation in neuroscience and the merging of neuroscience and education, she developed a reading comprehension intervention programme.

Reading remains important

Contrary to what we believe, the world is not more visual – but rather more technical, Dr Goldfus explains, and reading with understanding remains of utmost importance in the twenty first century. “Literacy does not only mean reading, but also thinking fast,” she says, “with the ability to sift through the mass of available information. Without reading proficiency, people cannot succeed in a world with so much information. In fact, the ability to identify what is important, and what not, is more crucial than before.”

““It is our duty to give
pupils worldwide the ability
to cope with a sophisticated,
alienated, and technological world.”
—Dr Carol Goldfus
ULFE

One brain, many languages

Reading comprehension is the epicentre of Dr Goldfus’s approach to learning, and her intervention programme may benefit any pupil who is unable to cope with the demands of the academic setting, and can be applied to any language. These pupils include children from seventh to twelth grade (12 to 18 years of age) who read without comprehension, have dyslexia, dyscalculia (problems with maths), and ADHD (Attention Deficit with or without Hyperactivity), or have dropped out of an education setting. “My intervention programme is in English as a Foreign Langue (EFL) but is not static, since it is based on principles from neuroscience and linguistics that are placed in the world of education. Although it is for EFL, it has a backwash effect on mother-tongue reading competence as well. Each programme comprises certain core principles, like developing self-esteem, monitoring comprehension and learning, and developing long-term memory storage. Without remembering, there is no learning.”

No one wants to fail

Dr Goldfus feels that it is our duty to give pupils worldwide the ability to cope with a sophisticated, alienated, and technological world. “My goal is to turn failure into excellence through an understanding of how the brain works. That is what the programme and my research can offer: creating a brain that can support learning where each pupil can fulfil his or her potential.”

Her work is so noteworthy, that Dr Goldfus received a Blue Skies Grand from the National Research Foundation of South Africa for her research: Graphomotor synchronisation to musical stimulation as a diagnostic tool for dyslexia. This proposed interdisciplinary research addresses dyslexia, a language-related disability, through the language of music and encompasses three disciplines: music cognition, physics and education.

News Archive

UFS study on cell development in top international science journal
2008-09-16

A study from the University of the Free State (UFS) on how the change in the packaging of DNA with cell development influenced the expression of genes, will be published in this week’s early edition of the prestigious international, peer-reviewed science journal, the Proceeding of the National Academy of Sciences of the USA (PNAS).

The PNAS journal has an impact factor of 10, which means that studies published in the journal are, on average, referred to by ten other scientific studies in a two year period. The South African Journal of Science, by comparison, has an impact factor of 0.7.

The UFS study, funded by the Wellcome Trust and the National Research Foundation (NRF), looked at how the change in the packaging of DNA with cell development influenced the expression of genes. It is very relevant to research on stem cells, an area of medicine that studies the possible use of undifferentiated cells to replace damaged tissue.

Prof. Hugh Patterton, of the Department of Microbial, Biochemical and Food Biotechnology at the UFS, who led the study, said: "We are extremely proud of this study. It was conceived in South Africa, it was performed in South Africa, the data were analysed in South Africa, and it was published from South Africa."

When a gene is expressed, the information encoded in the gene is used to manufacture a specific protein. In eukaryotes, which include humans, there is approximately 1m of DNA, containing the genes, in every cell. This length of DNA has to fit into a cell nucleus with a diameter of only about 10 micrometer. In order to fit the DNA into such a small volume, eukaryotic cells wrap their DNA onto successive protein balls, termed nucleosomes. Strings of nucleosomes, resembling a bead of pearls, is folded into a helix to form a chromatin fiber. The study from the UFS investigated how the binding of a specific protein, termed a linker histone, that binds to the length of DNA between nucleosomes, influenced the formation of the chromatin fiber and also the activity of genes.

"We found that the linker histone bound to chromatin in yeast, which we use as a model eukaryote, under conditions where virtually all the genes in the organism were inactive. It was widely believed that the binding of the linker histone caused the inactivation of genes. We studied the relationship between the amount of linker histone bound in the vicinity of each gene and the expression of that gene for all the genes in yeast, using genomic techniques. We made the surprising discovery that even through the linker histone preferentially bound to genes under conditions where the genes were shut off, this inactivation of genes was not caused by the binding of the linker histone and folding of the chromatin,” said Prof. Patterton.

He said: “Instead our data strongly suggested that the observed anti-correlation was due to the movement of enzymes along the DNA molecule, involved in processing the information in genes for the eventual manufacture of proteins. This movement of enzymes displaced the linker histones from the DNA. This finding now requires a rethink on aspects of how packaging of DNA influences gene activity."

Prof. Patterton said that his research group, using the Facility for Genomics and Proteomics as well as the Bioinformatics Node at the UFS, was currently busy with follow-up studies to understand how other proteins in nucleosomes affected the activities of genes, as well as with projects to understand how chemicals found in red wine and in green tea extended lifespan. "We are certainly having a marvelous time trying to understand the fundamental mechanisms of life, and the UFS is an exciting place to be if one was interested in studying life at the level of molecules," he said.


Media Release
Issued by: Lacea Loader
Assistant Director: Media Liaison
Tel: 051 401 2584
Cell: 083 645 2454
E-mail: loaderl.stg@ufs.ac.za  
18 September 2008
 

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